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Namalva cells were propagated continuously over a period of up to 18 months. During this period the chromosomal status of the cell populations were investigated cytogenetically. The ability of the cells to produce interferons after induction with Sendai vi ...
Copy-number variations (CNVs) are widespread in the human genome, but comprehensive assignments of integer locus copy-numbers (i.e., copy-number genotypes) that, for example, enable discrimination of homozygous from heterozygous CNVs, have remained challen ...
Visual backward masking (BM) deficits are often proposed to be trait markers for schizophrenia revealing the genetic underpinnings of the disease. Here, we show that, indeed, masking deficits in the shine-through effect are associated with polymorphisms in ...
Visual backward masking (BM) deficits are often proposed to be trait markers for schizophrenia, revealing the genetic underpinnings of the disease. Here, we show that masking deficits in the shine-through effect are associated with polymorphisms in the nic ...
Background: Information on nucleotide diversity along completely sequenced human genomes has increased tremendously over the last few years. This makes it possible to reassess the diversity status of distinct receptor proteins in different human individual ...
Levels of nucleotide diversity vary greatly across the genomes of most species owing to multiple factors. These include variation in the underlying mutation rates, as well as the effects of both direct and linked selection. Fundamental to interpreting the ...
Aim Propagule size and ecological requirements are believed to be major factors influencing the passive dispersal of free-living terrestrial protists. We compared the colonization potential of three closely related testate amoeba species (Assulina muscoru ...
Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained b ...
We present a new haplotype-based statistic (nS(L)) for detecting both soft and hard sweeps in population genomic data from a single population. We compare our new method with classic single-population haplotype and site frequency spectrum (SFS)-based metho ...
Peroxisome proliferator-activated receptor-gamma (PPARgamma) plays a role in adipocyte differentiation and insulin sensitization. We identified and characterized a new C/T substitution at position -689 (-689C>T) in the P2 promoter of PPARgamma in a putativ ...