Concept

Glycomics

Publications associées (48)

Numerical experiments with MALDI Imaging data

Pierre Vandergheynst, Mohammad Golbabaee

This article does not present new mathematical results, it solely aims at discussing some numerical experiments with MALDI Imaging data. However, these experiments are based on and could not be done without the mathematical results obtained in the UNLocX p ...

Springer2014

Serum antiglycan antibody detection of nonmucinous ovarian cancers by using a printed glycan array

Darlene Goldstein

Epithelial ovarian cancer has the highest mortality rate among gynecological cancers. Altered glycosylation is associated with oncogenic transformation producing tumor-associated carbohydrate antigens. We investigated the potential of natural occurring ant ...

2012

Combination of Gas-Phase Fractionation and MS3 Acquisition Modes for Relative Protein Quantification with Isobaric Tagging

Loïc Dayon, Martin Kussmann

Relative quantification of peptides and proteins with isobaric tags such as iTRAQ or TMT is commonly used in comparative quantitative proteomics based on tandem mass spectrometry (MS/MS). Nonetheless, isobaric tagging inherently suffers from the cofragment ...

Amer Chemical Soc2012

Transduction of Glycan-Lectin Binding Using Near-Infrared Fluorescent Single-Walled Carbon Nanotubes for Glycan Profiling

Ardemis Anoush Boghossian

There is significant interest in developing new detection platforms for characterizing glycosylated proteins, despite the lack of easily synthesized model glycans or high affinity receptors for this anal. problem. In this work, the authors demonstrate a se ...

2011

Real-Time Bioluminescence Imaging of Glycans on Live Cells

Cell-surface glycans are attractive targets for molecule imaging due to their reflection of cellular processes associated with development and disease progression. In this paper, we describe the design, synthesis, and biological application of a new phosph ...

American Chemical Society2010

N-glycan structures: recognition and processing in the ER

Maurizio Molinari, Riccardo Bernasconi

The processing of Winked glycans determines secretory protein homeostasis in the eukaryotic cell. Folding and degradation of glycoproteins in the endoplasmic reticulum (ER) are regulated by molecular chaperones and enzymes recruited by specific oligosaccha ...

2010

Electrospray Micromixer Chip for On-Line Derivatization and Kinetic Studies

Hubert Girault, Niels Erik Lion, Loïc Dayon, Mélanie Abonnenc, Brice Perruche

An electrospray microchip for mass spectrometry comprising an integrated passive mixer to carry out on-chip chemical derivatizations is described. The microchip fabricated using UV-photoablation is composed of two microchannels linked together by a liquid ...

2008

Specific On-Plate Enrichment of Phosphorylated Peptides for Direct MALDI-TOF MS Analysis

Hubert Girault, Christophe Roussel, Liang Qiao, Jingjing Wan

An on-plate specific enrichment method is presented for the direct analysis of peptides phosphorylation. An array of sintered TiO2 nanoparticle spots was prepared on a stainless steel plate to provide porous substrate with a very large specific surface and ...

American Chemical Society2007

Gel-free IEF in a membrane-sealed multicompartment cell for proteome prefractionation

Hubert Girault, Hoang-Trang Lam

A minidevice for performing gel-free proteome prefractionation via conventional IEF in soluble carrier ampholyte buffers is reported here. It consists of a compact block of poly-oxymethylene in which eight samples and two electrode chambers are machined. E ...

2007

NMR microimaging of fluid flowin model string-type reactors

Lioubov Kiwi

Magnetic resonance microimaging (MRM) was employed to obtain quantitative velocity maps of water flowing in the channels possessing unconventional cross-section shapes formed by a bundle of parallel fibers within a tubular string-type reactor. The maps obt ...

2007

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