Concept

Glutamate monosodique

Publications associées (32)

Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized H-1 and N-15 NMR spectroscopy

Rolf Gruetter, Cristina Ramona Cudalbu, Bernard Lanz, Yves Pilloud, João Miguel das Neves Duarte

Brain glutamine synthetase (GS) is an integral part of the glutamate-glutamine cycle and occurs in the glial compartment. In vivo Magnetic Resonance Spectroscopy (MRS) allows noninvasive measurements of the concentrations and synthesis rates of metabolites ...

Nature Publishing Group2012

N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development

Rolf Gruetter, João Miguel das Neves Duarte, Kim Do

Background: Glutathione (GSH) is the major cellular redox-regulator and antioxidant. Redox-imbalance due to genetically impaired GSH synthesis is among the risk factors for schizophrenia. Here we used a mouse model with chronic GSH deficit induced by knock ...

2012

Selective Glutamate Biosensor Arrays Integrated on Silicon Microprobes for In vivo Brain Recordings

Nico de Rooij, Peter Van der Wal, Olivier Frey

Real-time monitoring of glutamate, being the primary excitatory neurotransmitter, is of utmost importance for understanding the functioning of the central nervous system. Since expected concentrations and its variation in the brain are in the range of 0.5 ...

2010

Role of glutamate in neuron-glia metabolic coupling

Pierre Magistretti

The coupling between synaptic activity and glucose utilization (neurometabolic coupling) is a central physiologic principle of brain function that has provided the basis for 2-deoxyglucose-based functional imaging with positron emission tomography. Approxi ...

2009

A Micro-Electrode Array device coupled to a laser-based system for the local stimulation of neurons by optical release of glutamate

Diego Ghezzi

Optical stimulation is a promising approach to investigate the local dynamic responses of cultured neurons. In particular, flash photolysis of caged compounds offers the advantage of allowing the rapid change of concentration of either extracellular or int ...

Elsevier2008

Mammalian motor neurons corelease glutamate and acetylcholine at central synapses

Jesper Ryge

Motor neurons (MNs) are the principal neurons in the mammalian spinal cord whose activities cause muscles to contract. In addition to their peripheral axons, MNs have central collaterals that contact inhibitory Renshaw cells and other MNs. Since its origin ...

National Academy of Sciences2005

Relationship between L-glutamate-regulated intracellular Na+ dynamics and ATP hydrolysis in astrocytes

Pierre Magistretti, Jean-Yves Chatton

Glutamate uptake into astrocytes and the resulting increase in intracellular Na+ (Na+(i)) have been identified as a key signal coupling excitatory neuronal activity to increased glucose utilization. Arguments based mostly on mathematical modeling led to th ...

2004

Whole-brain glutamate metabolism evaluated by steady-state kinetics using a double-isotope procedure: effects of gabapentin

Rolf Gruetter

Cerebral rates of anaplerosis are known to be significant, yet the rates measured in vivo have been debated. In order to track glutamate metabolism in brain glutamatergic neurons and brain glia, for the first time unrestrained awake rats were continuously ...

Wiley-Blackwell2004

1H-localized broadband 13C NMR spectroscopy of the rat brain in vivo at 9.4 T

Rolf Gruetter

Localized (13)C NMR spectra were obtained from the rat brain in vivo over a broad spectral range (15-100 ppm) with minimal chemical-shift displacement error (

Wiley-Blackwell2003

Leptin: cutting the fat off the bone

Johan Auwerx

CONTEXT: Leptin was initially proposed to be the antiobesity hormone. Now it is realised that leptin is more a signal molecule that communicates nutritional status to the brain, and that it is involved in bone formation by having an antiosteogenic action. ...

2003

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