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Metallothioneins (MTs) constitute a class of low molecular weight, cysteine-rich, metal binding proteins which are regulated at the level of gene transcription in response to heavy metals and other adverse treatments. We have previously cloned a zinc finge ...
The evolution of metazoan body plans has involved changes to the Hox genes, which are involved in patterning the body axis and display striking evolutionary conservation of structure and expression. Invertebrates contain a single Hox cluster whereas tetrap ...
Expression of the human transferrin receptor (hTR) and its mRNA is strongly induced by iron deprivation. By measuring transcription elongation rates, levels of hTR-specific nuclear RNA, and mRNA half-lives, we found this regulation to occur posttranscripti ...
Preliminary work confirmed the important contribution of regional scale processes on pollutant concns. obsd. at local scales. For Grenoble, France, the model domain for simulations discussed, was selected considering the topog., urban area distribution, bo ...
A distributed system is no longer confined to a single administrative domain. Peer-to-peer applications and business-to-business e-commerce systems, for example, typically span multiple local-area and wide-area networks, raising issues of trust, security, ...
Secretins, a superfamily of multimeric outer membrane proteins, mediate the transport of large macromolecules across the outer membrane of Gramnegative bacteria. Limited proteolysis of secretin PulD from the Klebsiella oxytoca pullulanase secretion pathway ...
The receptor that mediates the specific uptake and intracellular transport of dimeric immunoglobulin A (IgA dimer) in mucosal and glandular epithelia is identical with a transmembrane precursor of secreted secretory component. During transport, the IgA dim ...
This document presents a new research domain in the area of communication systems. It is meant to be the proposal of the Communication Systems Division of EPFL and its Consortium to the National Pole of Competence of the Swiss National Fund. The expected ( ...
The conformations of melittin, porin, and lactose permease reconstituted in liposomal membranes were investigated by Raman spectroscopy, and the folding of membrane domains was predicted. These data resulted in consistent models for the insertion of the pr ...
While the existence of cholesterol/sphingolipid (raft) membrane domains in the plasma membrane is now supported by strong experimental evidence, the structure of these domains, their size, their dynamics, and their molecular composition remain to be unders ...
