Publications associées à Reeline

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation

Genes implicated in translation control have been associated with autism spectrum disorders (ASDs). However, some important genetic causes of autism, including the 16p11.2 microdeletion, bear no obvious connection to translation. Here, we use proteomics, g ...

Amer Assoc Advancement Science2024

Agency Deficits in a Human Genetic Model of Schizophrenia: Insights From 22q11DS Patients

Olaf Blanke, Nathan Quentin Faivre, Roy Salomon, Maude Schneider, Oliver Alan Kannape, Mariia Kaliuzhna, Henrique Galvan Debarba

Schizophrenia is a chronic and disabling mental illness characterized by a disordered sense of self. Current theories suggest that deficiencies in the sense of control over one’s actions (Sense of Agency, SoA) may underlie some of the symptoms of schizophr ...

2022

The critical periods of cerebral plasticity: A key aspect in a dialog between psychoanalysis and neuroscience centered on the psychopathology of schizophrenia

Pierre Magistretti

Through research into the molecular and cellular mechanisms that occur during critical periods, recent experimental neurobiological data have brought to light the importance of early childhood. These have demonstrated that childhood and early environmental ...

FRONTIERS MEDIA SA2022

Lactate supply overtakes glucose when neural computational and cognitive loads scale up

Pierre Magistretti

Neural computational power is determined by neuroenergetics, but how and which energy substrates are allocated to various forms of memory engram is unclear. To solve this question, we asked whether neuronal fueling by glucose or lactate scales differently ...

National Academy of Sciences2022

A functional model of adult dentate gyrus neurogenesis

Wulfram Gerstner, Olivia Gozel

In adult dentate gyrus neurogenesis, the link between maturation of newborn neurons and their function, such as behavioral pattern separation, has remained puzzling. By analyzing a theoretical model, we show that the switch from excitation to inhibition of ...

2021

Extensive and diverse patterns of cell death sculpt neural networks in insects

Pavan P Ramdya, Chin-Lin Chen

Changes to the structure and function of neural networks are thought to underlie the evolutionary adaptation of animal behaviours. Among the many developmental phenomena that generate change programmed cell death (PCD) appears to play a key role. We show t ...

2020

From adult dentate gyrus neurogenesis to pattern separation

Olivia Gozel

For a few decades, adult dentate gyrus neurogenesis has been widely recognized by the neuroscience community as an intriguing phenomenon. Two observations are particularly puzzling. At the cellular level, the switch from excitation to inhibition of the GAB ...

EPFL2019

Fast and robust estimation of NODDI parameters using non-Gaussian noise models and spatial regularization

Jean-Philippe Thiran, Erick Jorge Canales Rodriguez, Alessandro Daducci

In this study, we developed a robust inversion algorithm to estimate the Neurite Orientation Dispersion and Density Imaging (NODDI) model. It is based on the Accelerated Microstructure Imaging via Convex Optimization (AMICO) framework. However, in contrast ...

2018

Towards a supervised classification of neocortical interneuron morphologies

Sean Lewis Hill, Ruth Benavides Piccione, Bojan Mihaljevic

BackgroundThe challenge of classifying cortical interneurons is yet to be solved. Data-driven classification into established morphological types may provide insight and practical value.ResultsWe trained models using 217 high-quality morphologies of rat so ...

2018

Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone

Freddy Radtke

Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate through the rostral migratory stream (RMS). To ...

2018