Concept

Transport membranaire

Publications associées (147)

A high-performance silicon micropump for disposable drug delivery systems

This paper describes the design, fabrication and experimental results of a new, low cost, high-performance silicon micropump developed for a disposable drug delivery system. The pump chip demonstrates linear and accurate (+/-5%) pumping characteristics for ...

2001

Surface dynamics of aerolysin on the plasma membrane of living cells

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

Aerolysin secreted by the human pathogen Aeromonas hydrophila belongs to a group of bacterial toxins that are hemolytic and form channels in biological membranes. The toxin is secreted as an inactive precursor proaerolysin that must be proteolytically proc ...

2000

High resolution AFM topographs of the Escherichia coli water channel aquaporin Z

Henning Paul-Julius Stahlberg, Andreas Engel

Aquaporins form a large family of membrane channels involved in osmoregulation, Electron crystallography has shown monomers to consist of six membrane spanning a-helices confirming sequence based predictions. Surface exposed loops are the least conserved r ...

Wiley-Blackwell1999

Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family

Lukas Kühn

Amino acid transport across cellular membranes is mediated by multiple transporters with overlapping specificities. We recently have identified the vertebrate proteins which mediate Na+-independent exchange of large neutral amino acids corresponding to tra ...

1999

Ion transport across membranes prepared by gel crystallization

Harm-Anton Klok

A one-step procedure for the preparation of ion-selective membranes is described. The method employs the thermally induced gel crystallization of ultrahigh molecular weight poly(ethylene) (UHMW-PE) from a dilute xylene solution. After evaporation of the xy ...

1998

Conformational changes due to membrane binding and channel formation by staphylococcal alpha-toxin

Françoise Gisou van der Goot Grunberg

Conformational changes occurring upon membrane binding and subsequent insertion of staphylococcal alpha-toxin were studied using complementary spectroscopic techniques. Experimental conditions were established where binding could be uncoupled from membrane ...

1997

Novel benzo-15-crown-5 functionalized α-olefin/CO terpolymers for membrane applications

Harm-Anton Klok

The synthesis of a benzo-15-crown-5 functionalized α-olefin (4′-(undec-10-enylcarboxylate)benzo-15-crown-5, 5) and its terpolymerization with carbon monoxide and various α-olefins are described. A decline of the glass transition temperatures (Tg) of the co ...

1997

Structural characterisation and membrane insertion of M13 procoat, M13 coat and Pf3 coat proteins

Membrane proteins fulfill many central functions in the biological membrane. The insertion process of these proteins and their structure, which are intimately linked to their function, are not yet well understood. As a model we studied three proteins recon ...

EPFL1996

All in the family: the toxic activity of pore-forming colicins

Françoise Gisou van der Goot Grunberg

Colicins are unusual bacterial toxins because they are directed against close relatives of the producing strain. They kill their targets in one of three distinct ways; via a ribonuclease or deoxyribonuclease activity or by forming pores in the target cell' ...

1994

Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65

Steinunn Baekkeskov Hanahan

The smaller isoform of the GABA synthesizing enzyme glutamic acid decarboxylase, GAD65, is synthesized as a soluble protein that undergoes posttranslational modification(s) in the NH2-terminal region to become anchored to the membrane of small synaptic-lik ...

1994

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