Concept
Antihypertenseur
Publications associées (40)
Modulation of Pulsatile Left Ventricular Afterload by Renal Denervation in Heart Failure With Preserved Ejection Fraction
Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou
Background:Arterial stiffening contributes to hemodynamic derangements in heart failure with preserved ejection fraction (HFpEF). We sought to investigate the impact of renal denervation on pulsatile left ventricular loading in patients with HFpEF and hype ...
Philadelphia2023Effect of the structural modification of Candesartan with Zinc on hypertension and left ventricular hypertrophy
Nikolaos Stergiopoulos, Augusto Martins Lima, Valeria Romina Martinez
Hypertension is the most common cause of left ventricular hypertrophy, contributing to heart failure progression. Candesartan (Cand) is an angiotensin receptor antagonist widely used for hypertension treatment. Structural modifications were previously perf ...
ELSEVIER2023Zinc complexation improves angiotensin II receptor type 1 blockade and in vivo antihypertensive activity of telmisartan
Nikolaos Stergiopoulos, Augusto Martins Lima, Valeria Romina Martinez
Background: Angiotensin II receptor blockers were designed as therapeutic agents to block the binding site of the angiotensin II receptor type 1 (AT1R). Methodology: The structure of telmisartan was modified by coordination to the biometal Zn(II), resultin ...
FUTURE SCI LTD2020Organometallic Glutathione S-Transferase Inhibitors
Paul Joseph Dyson, Rosario Scopelliti, Mylène Soudani, Emilia Paunescu
A new family of organometallic p-cymene ruthenium(II) and osmium(II) complexes conjugated to ethacrynic acid, a glutathione transferase (GST) inhibitor, is reported. The ethacrynic acid moiety (either one or two) is tethered to the arene ruthenium(II) and ...
2017Arene Osmium Complexes with Ethacrynic Acid-Modified Ligands: Synthesis, Characterization, and Evaluation of Intracellular Glutathione S-Transferase Inhibition and Antiproliferative Activity
Paul Joseph Dyson, Tina Riedel, Emilia Paunescu
Four arene osmium complexes were prepared containing derivatives of ethacrynic acid, a potent inhibitor of glutathione Stransferases, either by direct coordination or via N- or P-donor ligands. The complexes were characterized by spectroscopic and analytic ...
American Chemical Society2016