Concept

Maladie de Crohn

Publications associées (49)

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

Johan Auwerx, Kristina Schoonjans, Laurent Mouchiroud, Dongryeol Ryu, Alessandra Piersigilli, Elena Katsyuba, Giuseppe Lo Sasso

Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial ...

Public Library of Science2014

Systems Biology Approaches for Inflammatory Bowel Disease: Emphasis on Gut Microbial Metabolism

Martin Kussmann, Sofia Moco

Although the prevalence of main idiopathic forms of inflammatory bowel disease (IBD) has risen considerably over the last decades, their clinical features do not allow accurate prediction of prognosis, likelihood of disease progression, or response to spec ...

Lippincott Williams & Wilkins2014

Inhibition of Sepiapterin Reductase through Formation of a Ternary Complex with Sulfasalazine or other Sulfa Drugs and NADP+

Miriam Grønlund Pedersen

The mechanism of action of sulfasalazine, an anti-inflammatory drug used against inflammatory bowel diseases and rheumatoid arthritis is, despite its medical importance, still not well understood. Recently, it was shown that sulfasalazine and its metabolit ...

EPFL2014

Privacy-Preserving Computation of Disease Risk by Using Genomic, Clinical, and Environmental Data (poster version)

Jean-Pierre Hubaux, Jacques Fellay, Erman Ayday, Jean Louis Raisaro

Privacy-Preserving Computation of Disease Risk by Using Genomic, Clinical, and Environmental Data ...

2013

Selective in vivo visualization of immune-cell infiltration in a mouse model of autoimmune myocarditis by fluorine-19 cardiac magnetic resonance

Ruud van Heeswijk

Background- The goal of this study was to characterize the performance of fluorine-19 ((19)F) cardiac magnetic resonance (CMR) for the specific detection of inflammatory cells in a mouse model of myocarditis. Intravenously administered perfluorocarbons are ...

2013

Intestinal bacteria induce TSLP to promote mutualistic T-cell responses

Nicola Harris, Mario Michael Zaiss, Ilaria Mosconi

Thymic stromal lymphopoietin (TSLP) is constitutively expressed in the intestine and is known to regulate inflammation in models of colitis. We show that steady-state TSLP expression requires intestinal bacteria and has an important role in limiting the ex ...

Nature Publishing Group2013

Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease

Jacques Fellay

Variation in the 3' untranslated region (3'UTR) of the HLA-C locus determines binding of the microRNA Hsa-miR-148a, resulting in lower cell surface expression of alleles that bind miR-148a relative to those alleles that escape its binding. The HLA-C 3'UTR ...

Natl Acad Sciences2013

HVEM Signalling Promotes Colitis

Nicola Harris, Stefanie Hiltbrunner

Tumor necrosis factor super family (TNFSF) members regulate important processes involved in cell proliferation, survival and differentiation and are therefore crucial for the balance between homeostasis and inflammatory responses. Several members of the TN ...

Public Library of Science2011

Emerging actions of the nuclear receptor LRH-1 in the gut

Johan Auwerx, Kristina Schoonjans

Liver receptor homolog-1 (NR5A2) is a nuclear receptor originally identified in the liver and mostly known for its regulatory role in cholesterol and bile acid homeostasis. More recently, liver receptor homolog-1 has emerged as a key regulator of intestina ...

2011

Compositions and use of sulfasalazine

Kai Johnsson, Christopher Chidley

The invention relates to compositions comprising sulfasalazine or sulfapyridine and products of a biosynthetic pathway that requires tetrahydrobiopterin. Such compositions are useful for the treatment of inflammatory bowel diseases or rheumatoid arthritis, ...

2011

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