Concept

Maladie de Crohn

Publications associées (49)

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin

Simona Frateschi, Friedrich Beermann, Anne Wilson, Roch-Philippe Charles

Altered serine protease activity is associated with skin disorders in humans and in mice. The serine protease channel-activating protease-1 (CAP1; also termed protease serine S1 family member 8 (Prss8)) is important for epidermal homeostasis and is thus in ...

2011

Lipopolysaccharide induces intestinal glucocorticoid synthesis in a TNFalpha-dependent manner

Kristina Schoonjans

Stringent control of immune responses in the intestinal mucosa is critical for the maintenance of immune homeostasis and prevention of tissue damage, such as observed during inflammatory bowel disease. Intestinal epithelial cells, primarily thought to form ...

2010

Instrumentation of a Clinical Colonoscope for Surgical Simulation

Hannes Bleuler, Evren Samur, Lionel Flaction, Pascal Maillard

This paper describes the instrumentation of a clinical colonoscope needed for a novel colonoscopy simulation framework. The simulator consists of a compact and portable haptic interface and a virtual reality environment to provide real-time visualization. ...

2008

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

Johan Auwerx, Kristina Schoonjans

Liver receptor homolog-1 (LRH-1) is a nuclear receptor involved in intestinal lipid homeostasis and cell proliferation. Here we show that haploinsufficiency of LRH-1 predisposes mice to the development of intestinal inflammation. Besides the increased infl ...

2007

Design of a light delivery system for the photodynamic treatment of the Crohn's disease

Hubert van den Bergh, Georges Wagnières, Tanja Gabrecht, François André Borle

Crohn's disease is an inflammatory bowel disease originating from an overwhelming response of the mucosal immune system. Low dose photodynamic therapy (PDT) may modify the mucosal immune response and thus serve as a therapy for Crohn's disease. Most patien ...

2007

Photodynamic therapy as a novel therapeutic approach for the treatment of Crohn's disease

Hubert van den Bergh, Georges Wagnières, Dominique Velin

Photodynamic therapy (PDT) may modify the mucosal immune response and thus serve as a therapy for Crohn’s disease (CD). After evaluating safety in BALB/c mice and establishing an endoscopic index of colitis (EIC), we could demonstrate that a single «low do ...

2006

Relations between perceived indoor environment characteristics and well being of occupants at individual level

Claude-Alain Roulet

Within the European research project HOPE, 97 apartmentbuildings and 67 office buildings were investigated using checklists addressing the building characteristics and self-administered questionnaires to the occupants asking their perceived comfort (therma ...

2006

Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma

Johan Auwerx, Walter Wahli

5-aminosalicylic acid (5-ASA) is an antiinflammatory drug widely used in the treatment of inflammatory bowel diseases. It is known to inhibit the production of cytokines and inflammatory mediators, but the mechanism underlying the intestinal effects of 5-A ...

2005

Intraarticular application of superparamagnetic nanoparticles and their uptake by synovial membrane—an experimental study in sheep

Heinrich Hofmann, Benedikt Steitz, Mathieu Chastellain

A superparamagnetic iron oxide nanoparticle, coated with polyvinyl alcohol, (PVA-SPION) and its fluorescently functionalized analogue (amino-PVA-Cy3.5-SPION) were compared in vivo as proof of principle for future use in magnetic drug targeting in inflammat ...

2005

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Freddy Radtke

The self-renewing epithelium of the small intestine is ordered into stem/progenitor crypt compartments and differentiated villus compartments. Recent evidence indicates that the Wnt cascade is the dominant force in controlling cell fate along the crypt-vil ...

2005

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