Concept

Acide glutamique

Publications associées (165)

Fine tuning of the catalytic effect of a metal-free porphyrin on the homogeneous oxygen reduction

The catalytic effect of tetraphenylporphyrin on the oxygen reduction with ferrocene in 1,2-dichloroethane can be finely tuned by varying the molar ratio of the acid to the catalyst present in the solution. The mechanism involves binding of molecular oxygen ...

Royal Society of Chemistry2011

Selective Glutamate Biosensor Arrays Integrated on Silicon Microprobes for In vivo Brain Recordings

Nico de Rooij, Peter Van der Wal, Olivier Frey

Real-time monitoring of glutamate, being the primary excitatory neurotransmitter, is of utmost importance for understanding the functioning of the central nervous system. Since expected concentrations and its variation in the brain are in the range of 0.5 ...

2010

Enzyme-based choline and l-glutamate biosensor electrodes on silicon microprobe arrays

Nico de Rooij, Peter Van der Wal, Olivier Frey

Brain-implantable microprobe arrays, 6.5 mm shaft-length, incorporating several recessed Pt microelectrodes (50 mu m x 150 mu m) and an integrated Ag/AgCl reference electrode fabricated by silicon micromachining dry etching techniques (DRIE) are described. ...

Elsevier2010

Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clusters

Steinunn Baekkeskov Hanahan

T he inhibitory neurotransmitter gamma-amino butyric acid (GABA) is synthesized by two isoforms of the enzyme glutamic acid decarboxylase (GAD): GAD65 and GAD67. Whereas GAD67 is constitutively active and produces >90% of GABA in the central nervous system ...

Rockefeller University Press2010

Role of glutamate in neuron-glia metabolic coupling

Pierre Magistretti

The coupling between synaptic activity and glucose utilization (neurometabolic coupling) is a central physiologic principle of brain function that has provided the basis for 2-deoxyglucose-based functional imaging with positron emission tomography. Approxi ...

2009

Experimentally Facile Controlled Polymerization of N-Carboxyan hydrides (NCAs), Including O-Benzyl-L-threonine NCA

Matthew Gibson

It is demonstrated here that three different alpha-amino N-carboxyanhydrides (NCAs), including for the first time O-benzyl-L-threonine NCA, can be polymerized in a controlled/"living" fashion without the need for transition metal catalysts or complex custo ...

2009

Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration

Harald Hirling, Nikita Rudinskiy

Clathrin-dependent endocytosis is mediated by a tightly regulated network of molecular interactions that provides essential protein-protein and protein-lipid binding activities. Here we report the hydrolysis of the alpha- and beta2-subunits of the tetramer ...

American Society for Biochemistry and Molecular Biology2009

Glial Energy Metabolism: A NMR Spectroscopy Perspective

Rolf Gruetter

Oxygen metabolism is uniquely compartmentalized between neurons and glia, the latter comprising about 25% of neuronal energy metabolism. The consumption of acetate and fixation of CO2 in glutamine occur in astrocytes by oxygen-dependent reactions, which po ...

Elsevier2009

Electron Capture Dissociation Product Ion Abundances at the X Amino Acid in RAAAA-X-AAAAK Peptides Correlate with Amino Acid Polarity and Radical Stability

Yury Tsybin, Hisham Ben Hamidane, Aleksey Vorobyev

We present mechanistic studies aimed at improving the understanding of the product ion formation rules in electron capture dissociation (ECD) of peptides and proteins in Fourier transform ion cyclotron resonance mass spectrometry. In particular, we attempt ...

Springer-Verlag2009

Simultaneous Chemical Recording and Stimulation in the Brain Using an Assembly of Biosensor Silicon Microprobes and SU-8 Microinjectors

Nico de Rooij, Peter Van der Wal, Olivier Frey

In this contribution we present multi-channel microinjector arrays fabricated by a reliable three-layer SU-8 process and assembled with glutamate biosensor microprobes1. It enables local delivery of specific liquids into brain tissue for the stimulation or ...

2009

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