Concept

Histidine

Publications associées (37)

On-line Electrogeneration of Copper-Peptide Complexes in Microspray Mass Spectrometry

The interaction of copper ions with peptides was investigated by electrospray mass spectrometry. Two electrospray micro-emitters were compared, the first one with a platinum electrode using a copper(II) electrolyte solution containing a peptide sample, and ...

2008

Revisiting Ether-Derivatized Imidazolium-Based Ionic Liquids

Paul Joseph Dyson, Rosario Scopelliti, Zhaofu Fei, Wee Han Ang, Dongbin Zhao

A series of ether-derivatized imidazolium halides have been prepd. and characterized. Contrary to literature reports, they are all cryst. solids and have m.ps. well above room temp. (50-100 °C). Single crystals of the imidazolium salts, obtained in situ by ...

2007

Conformation-specific spectroscopy and photodissociation of cold, protonated tyrosine and phenylalanine

Thomas Rizzo, Monia Guidi, Sébastien Mercier, Caroline Seaiby

We present here ultraviolet and infrared spectra of protonated aromatic amino acids in a cold, 22-pole ion trap. Ultraviolet photofragmentation spectra of protonated tyrosine and phenylalanine show vibronically resolved bands corresponding to different sta ...

2007

ZYG-9, TAC-1 and ZYG-8 together ensure correct microtubule function throughout the cell cycle of C. elegans embryos

Pierre Gönczy

The early Caenorhabditis elegans embryo is well suited for investigating microtubule-dependent cell division processes. In the one-cell stage, the XMAP215 homologue ZYG-9, associated with the TACC protein TAC-1, promotes microtubule growth during interphas ...

2007

Sulfide-binding hemoglobins: effects of mutations on active-site flexibility

Majed Chergui

The dynamics of Hb I (HbI) from the clam Lucina pectinata, from wild-type sperm whale (SW) myoglobin, and from the L29F/H64Q/V68F triple mutant of SW, both unligated and bound to hydrogen sulfide (H2S), have been studied in mol. dynamics simulations. Featu ...

2006

Triple Quantum Decoherence under Multiple Refocusing: Slow Correlated Chemical Shift Modulations of C' and N Nuclei in Proteins

Geoffrey Bodenhausen, Julien Wist

A new expt. allows the identification of residues that feature slow conformational exchange in macromols. Rotations about dihedral angles that are slower than the global correlation time tc cause a modulation of the isotropic chem. shifts of the nuclei. If ...

2004

A Bis-Carbenealkenyl Copper(I) Complex from a Tripodal Tris-Carbene Ligand

Xile Hu

The new tris-carbene ligand [TIMEt-Bu] has been synthesized and fully characterized. Reaction of the free carbene with copper(I) salt provided an unprecedented dinuclear Cu(I)-Cu(I) complex, in which the cuprous ion is coordinated in a trigonal planar liga ...

2003

Synthesis and Physicochemical Characterization of End-Linked Poly(ethylene glycol)-co-peptide Hydrogels Formed by Michael-Type Addition

Matthias Lütolf, Jeffrey Alan Hubbell

The synthesis of novel hybrid hydrogels by stepwise copolymn. of multi-arm vinyl sulfone-terminated poly(ethylene glycol) macromers and a-w cysteine oligopeptides via Michael-type addns. is described. Crosslinking kinetics, studied by in situ rheometry, ca ...

2003

Immobilization of histidine-tagged proteins on gold surfaces using chelator thioalkanes

Horst Vogel, Martha Liley

The reversible, oriented immobilization of proteins on solid surfaces is a prerequisite for the investigation of mol. interactions and the controlled formation of supramol. assemblies. This paper describes a generally applicable method using a synthetic ch ...

1999

High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase

Steinunn Baekkeskov Hanahan

The smaller isoform of the GABA-synthesizing enzyme, glutamic acid decarboxylase 65 (GAD65), is unusually susceptible to becoming a target of autoimmunity affecting its major sites of expression, GABA-ergic neurons and pancreatic β-cells. In contrast, a hi ...

Elsevier1999

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