Concept

Drug delivery

Publications associées (207)

Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation

Francesco Stellacci, Ye Yang, Ahmet Bekdemir, Marie Mueller

Although immunotherapy shows great promise for the long-term control of cancer, many tumors still fail to respond to treatment. To improve the outcome, the delivery of immunostimulants to the lymph nodes draining the tumor, where the antitumor immune respo ...

ELSEVIER SCI LTD2019

Design, Synthesis and in vitro Controlled Release of New Adamantanodiarylketone Antimycobacterials

Stewart Cole, Anthony Vocat

In the present investigation, the synthesis, the biology and the development of matrix tablet formulations for the in vitro controlled release of new adamantane diarylketone antimycobacterial derivatives, is presented. In the skeleton of the new compounds, ...

WILEY-V C H VERLAG GMBH2019

Identification of Factors of Importance for Spray Drying of Small Interfering RNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles for Inhalation

Background With the recent approval of the first small interfering RNA (siRNA) therapeutic formulated as nanoparticles, there is increased incentive for establishing the factors of importance for the design of stable solid dosage forms of such complex nano ...

2019

Biodegradable Frequency‐Selective Magnesium Radio‐Frequency Microresonators for Transient Biomedical Implants

Jürgen Brugger, Giovanni Boero, Matthieu Jean Michel Rüegg, Remo Blum

Bioresorbable implantable medical devices show a great potential for applications requiring medical care over well‐defined periods of time. Once their function is fulfilled, such implants naturally degrade and resorb in the body, which eliminates adverse l ...

2019

Soft Self-Healing Nanocomposites

Véronique Michaud, Yves Leterrier, Sravendra Rana

This review article provides an overview of the research and applications of soft self-healing polymers and their nanocomposites. A number of concepts based on physical and chemical interactions have been explored to create dynamic and reversible gel and e ...

FRONTIERS MEDIA SA2019

Surgery-free injectable macroscale biomaterials for local cancer immunotherapy

Li Tang, Kewen Lei

Immunotherapy can harness the power of host's immune system to fight cancer. In the last few decades, tremendous progress has been made in this field, with remarkable clinical successes achieved consisting of a durable response in a fraction of patients. H ...

2019

Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery

Yimon Aye, Bokyoung Kim

Protein-protein interactions (PPIs) are an effective means to orchestrate intricate biological processes required to sustain life. Approximately 650000 PPIs underlie the human interactome; thus underscoring its complexity and the manifold signaling outputs ...

WILEY-V C H VERLAG GMBH2019

pH-Sensitive Coiled-Coil Peptide-Cross-Linked Hyaluronic Acid Nanogels: Synthesis and Targeted Intracellular Protein Delivery to CD44 Positive Cancer Cells

Harm-Anton Klok, Jian Zhang, Yu Jiang

The clinical translation of protein drugs that act intracellularly is limited by the absence of safe and efficient intracellular protein delivery vehicles. Here, pH-sensitive coiled-coil peptide-cross-linked hyaluronic acid nanogels (HA-cNGs) were designed ...

2018

IoT Bio-Electronic Multi-Panel Device for On-line Monitoring of Anaesthesia Delivery

Francesca Stradolini

After a failure of "One-Size-Fits-All" approach on traditional treatment of diseases, the age of multi-faceted personalized medicine came into being for tailoring therapy to get the best response in the highest safety margin. Personalized drug dosage is on ...

EPFL2018

Electrostatically gated nanofluidic membranes: Technological developments and use of electrochemically polarizable materials

Stefano Silvio Giovanni Varricchio

Solid-state nanoporous membranes able to control ionic flows at the molecular level could have important applications in fields of research such as water filtration, nanomedicine, energy production, drug delivery, and bio-chemical analysis. The ability to ...

EPFL2018

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