Concept

Drug delivery

Publications associées (207)

Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity

Paul Joseph Dyson, Zhaofu Fei, Peng Huang

Multi-layered single-walled carbon nanotubes, t ermed SWNT@BSA@Au-S-PEG -FA@DOX, which int egrate photothermal therapy with small molecule drug delivery, were prepared using a facile layer-by-layer assembly process. Oxidized and eut single-walled carbon na ...

2018

Free-electron-laser coherent diffraction images of individual drug-carrying liposome particles in solution

Giorgio Margaritondo, Ying Chen, Ke Peng

Using the excellent performances of a SACLA (RIKEN/HARIMA, Japan) X-ray free electron laser (X-FEL), coherent diffraction imaging (CDI) was used to detect individual liposome particles in water, with or without inserted doxorubicin nanorods. This was possi ...

2018

Free-electron-laser coherent diffraction images of individual drug-carrying liposome particles in solution

Giorgio Margaritondo, Ke Peng

2018

Microfluidic Production of Capsules-in-Capsules for Programed Release of Multiple Ingredients

Esther Amstad

Capsules with thin shells have a high‐loading capacity and are thus well‐suited containers for reagents that must be stored in confined volumes. Capsules contained in larger capsules, so‐called double capsules, allow the encapsulation of distinct reagents ...

2018

Thermal-responsive biodegradable composite membrane for drug delivery application

Ya Wang

Drug delivery systems have been engineered in order to improve therapeutic performance and reduce the side effects of conventional delivery system like oral ingestion, subcutaneous injection [1-2]. There exist several types of drug delivery systems, among ...

2017

Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

Harm-Anton Klok, Claudia Battistella

Polymer nanomedicines are very attractive to improve the delivery of chemotherapeutics. Polymer conjugates and other polymer-based nanocarriers allow to increase plasma half-life and drug bioavailability and can also be guided toward tumors using passive a ...

2017

In vitro Controlled Release from Solid Pharmaceutical Formulations of two new Adamantane Aminoethers with Antitubercular Activity (I).

Stewart Cole, Anthony Vocat

The aim of the present investigation was to develop matrix tablet formulations for the in vitro controlled release of 2 new tuberculocidal adamantane aminoethers (compounds I and II), congeneric to the adamantane derivative SQ109 , which is in final clinic ...

Georg Thieme Verlag Kg2017

A Smart Europium-Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light Excitations

Jean-Claude Bünzli, Chen Xie

A unique, dual-function, photoactivatable anticancer prodrug, RuEuL, has been tailored that features a ruthenium(II) complex linked to a cyclen-europium chelate via a pi-conjugated bridge. Under irradiation at 488 nm, the dark-inactive prodrug undergoes ph ...

Amer Chemical Soc2017

Controlling and Monitoring Intracellular Drug Delivery Using PHPMA-Based Polymer Nanomedicines

Claudia Battistella

Polymer nanomedicine is an attractive approach for the delivery of anticancer drugs. Firstly designed to increase drug bioavailability, polymer conjugates and polymer nanoparticles have rapidly emerged in the field of cancer therapy after the discovery of ...

EPFL2017

TUCUXI: TUCUXI: An Intelligent System for Personalized Medicine from Individualization of Treatments to Research Databases and Back

Karl Aberer, Yann Thoma, Michael Ignaz Schumacher, Thierry Buclin, Alevtina Dubovitskaya

Therapeutic Drug Monitoring (TDM) is a key concept in precision medicine. The goal of TDM is to avoid therapeutic failure or toxic effects of a drug due to insufficient or excessive circulating concentration exposure related to between-patient variability ...

2017

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