Concept

Arginine

Publications associées (40)

Arginine-specific protein modification using alpha-oxo-aldehyde functional polymers prepared by atom transfer radical polymerization

Harm-Anton Klok, Maxime Ayer, Frederik Roman Wurm, Marc Gauthier, Justyna Kowal

The residue-specific modification of peptides and proteins is a powerful strategy for preparing biomolecular-synthetic polymer conjugates with advanced properties. This manuscript aims at expanding the present toolbox of residue-selective protein modificat ...

2011

Tailoring hydrogel degradation and drug release via neighboring amino acid-controlled ester hydrolysis

Matthias Lütolf, Jeffrey Alan Hubbell, Yun Suk Jo, Jay Gantz

We present a versatile scheme to rationally modulate the hydrolysis rate of ester bonds in hydrophilic polymer networks via adjacent charged amino acids. As soluble model systems, two cysteine-bearing oligopeptides containing either positively charged argi ...

2009

Exchange Rate Constants of Invisible Protons in Proteins Determined by NMR Spectroscopy

Geoffrey Bodenhausen

Although labile protons that are exchanging rapidly with those of the solvent cannot be observed directly, their exchange rate constants can be determined by indirect detection of scalar-coupled neighboring nuclei. We have used heteronuclear NMR spectrosco ...

2008

Structures of P. falciparum protein kinase 7 identify an activation motif and leads for inhibitor design

Malaria is a major threat to world health. The identification of parasite targets for drug development is a priority and parasitic protein kinases suggest themselves as suitable targets as many display profound structural and functional divergences from th ...

2008

The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria

Stewart Cole

Mycobacterium leprae protein ML2640c belongs to a large family of conserved hypothetical proteins predominantly found in mycobacteria, some of them predicted as putative S-adenosylmethionine (AdoMet)-dependent methyltransferases (MTase). As part of a Struc ...

2007

The thermal polymerization of amino acids revisited; Synthesis and structural characterization of hyperbranched polymers from L-lysine

Harm-Anton Klok, Markus Scholl

This contribution reports on the synthesis of hyperbranched polylysines via thermal polymerization of L-lysine hydrochloride. Polymerization of L-lysine hydrochloride in the presence of one equivalent KOH at 150°C resulted in polymers with a number-average ...

2007

Infrared photofragment spectroscopy of charged amino acid water clusters in the gas phase

Anthi Kamariotou

We present in this work a new technique, which combines laser photofragmentation spectroscopy with tandem mass spectrometry, for structural investigations of biomolecular ions in the gas phase. A novel apparatus was designed and built for the implementatio ...

EPFL2006

Microsolvation effects on the excited state dynamics of protonated tryptophan

Ursula Röthlisberger, Thomas Rizzo, Ivano Tavernelli, Michele Cascella, Sébastien Mercier, Matteo Guglielmi

To better understand the complex photophysics of the amino acid tryptophan, which is widely used as a probe of protein structure and dynamics, we have measured electronic spectra of protonated, gas-phase tryptophan solvated with a controlled number of wate ...

2006

Localized in vivo 13C NMR spectroscopy of the brain

Rolf Gruetter, Hongxia Lei

Localized (13)C NMR spectroscopy provides a new investigative tool for studying cerebral metabolism. The application of (13)C NMR spectroscopy to living intact humans and animals presents the investigator with a number of unique challenges. This review pro ...

Wiley-Blackwell2003

Examining reactivity and specificity of cytochrome c peroxidase by using combinatorial mutagenesis

Kai Johnsson, Claudio Arrivoli, Petra Tafelmeyer, Martin Wilming

Combinatorial mutagenesis was used to investigate the role of three key residues in cytochrome c peroxidase (CCP) from Saccharomyces cerevisiae, Arg48, Trp51, and Trp191, in control of the reactivity and selectivity of the heme-contg. enzyme. Libraries wer ...

2002

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