Concept

Clonus

Publications associées (21)

Altered sensory processing and dendritic remodeling in hyperexcitable visual cortical networks

Epilepsy is characterized by impaired circuit function and a propensity for spontaneous seizures, but how plastic rearrangements within the epileptic focus trigger cortical dysfunction and hyperexcitability is only partly understood. Here we have examined ...

Springer Heidelberg2016

Chondroitinase gene therapy improves upper limb function following cervical contusion injury

Bernard Schneider, Nicholas David James

Chondroitin sulphate proteoglycans (CSPGs) are known to be important contributors to the intensely inhibitory environment that prevents tissue repair and regeneration following spinal cord injury. The bacterial enzyme chondroitinase ABC (ChABC) degrades th ...

Elsevier2015

From lamprey to salamander: an exploratory modeling study on the architecture of the spinal locomotor networks in the salamander

Auke Ijspeert, Andrej Bicanski

The evolutionary transition from water to land required new locomotor modes and corresponding adjustments of the spinal "central pattern generators" for locomotion. Salamanders resemble the first terrestrial tetrapods and represent a key animal for the stu ...

Springer Berlin Heidelberg2013

The Future of Intracranial EEG Recording in Epilepsy: a Technological Issue?

Alexandre Schmid, Catherine Dehollain, Mahsa Shoaran, André Mercanzini, Yusuf Leblebici

Intracranial EEG information used for epilepsy surgery has been provided from large widely spaced electrodes over a narrow bandwidth. However, over the last decades, research on animal and more recently on human, promoted by increased interest in developin ...

2012

Multi-system neurorehabilitative strategies to restore motor functions following severe spinal cord injury

Grégoire Courtine, Pavel Musienko, Rubia van den Brand, Lucia Florinda Friedli Wittler

Severe spinal cord injury (SCI) permanently abolishes motor functions caudal to the lesion. However, the neuronal machinery sufficient to produce standing and stepping is located below most SCI, and can be reactivated with training. Therefore, why do rats ...

2012

Somatosensory control of balance during locomotion in decerebrated cat

Grégoire Courtine, Pavel Musienko

Postmammillary decerebrated cats can generate stepping on a moving treadmill belt when the brain stem or spinal cord is stimulated tonically and the hindquarters are supported both vertically and laterally. While adequate propulsion seems to be generated b ...

2012

Spinal cord reflexes induced by epidural spinal cord stimulation in normal awake rats

Grégoire Courtine

Motor responses in hindlimb muscles to epidural spinal cord stimulation in normal awake rats during bipedal standing were studied. Stimulation at L2 or S1 induced simultaneous and bilateral responses in the vastus lateralis, semitendinosus, tibialis anteri ...

2006

Mammalian motor neurons corelease glutamate and acetylcholine at central synapses

Jesper Ryge

Motor neurons (MNs) are the principal neurons in the mammalian spinal cord whose activities cause muscles to contract. In addition to their peripheral axons, MNs have central collaterals that contact inhibitory Renshaw cells and other MNs. Since its origin ...

National Academy of Sciences2005

Coding and Learning of behavioral sequences

Wulfram Gerstner, Henry Markram

A major challenge to understanding behavior is how the nervous system allows the learning of behavioral sequences that can occur over arbitrary timescales, ranging from milliseconds up to seconds, using a fixed millisecond learning rule. This article descr ...

2004

Seizure suppression by adenosine-releasing cells is independent of seizure frequency

Patrick Aebischer, Vivianne Padrun

PURPOSE: Intraventricular cellular delivery of adenosine was recently shown to be transiently efficient in the suppression of seizure activity in the rat kindling model of epilepsy. We tested whether the suppression of seizures by adenosine-releasing graft ...

2002

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