Concept

Reperfusion injury

Publications associées (55)

Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury

Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Quentin Barraud, Pavel Musienko, Rubia van den Brand, Lucia Florinda Friedli Wittler, Simone Ellen Joze Duis, Isabel Laura Vollenweider, Kay Alexander Bartholdi

Half of human spinal cord injuries lead to chronic paralysis. Here, we introduce an electrochemical neuroprosthesis and a robotic postural interface designed to encourage supraspinally-mediated movements in rats with paralyzing lesions. Despite the interru ...

2012

Mesenchymal stem cells restore cortical rewiring after neonatal ischemia in mice

Yohan Van de Looij

Objective: A study was undertaken to investigate the effect of neonatal hypoxic-ischemic (HI) brain damage and mesenchymal stem cell (MSC) treatment on the structure and contralesional connectivity of motor function-related cerebral areas. Methods: Brain r ...

Wiley-Blackwell2012

Update on the Role of Cannabinoid Receptors after Ischemic Stroke

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Luciano Dos Santos Aggum Capettini

Cannabinoids are considered as key mediators in the pathophysiology of inflammatory diseases, including atherosclerosis. In particular, they have been shown to reduce the ischemic injury after acute cardiovascular events, such as acute myocardial infarctio ...

Taylor & Francis2012

Longitudinal MR Assessment of Hypoxic Ischemic Injury in the Immature Rat Brain

Rolf Gruetter, Yohan Van de Looij

Extremely preterm infants commonly show brain injury with long-term structural and functional consequences. Three-day-old (P3) rat pups share some similarities in terms of cerebral development with the very preterm infant (born at 24-28 weeks of gestation) ...

Wiley-Blackwell2011

Ablation of the Tumor Suppressor Histidine Triad Nucleotide Binding Protein 1 is Protective Against Hepatic Ischemia/Reperfusion Injury

Gisèle Ferrand

The identification of cellular pathways capable of limiting ischemia/reperfusion (I/R) injury remains a frontier in medicine, and its clinical relevance is urgent. Histidine triad nucleotide binding protein 1 (HINT1) is a tumor suppressor that influences a ...

2011

Early Predictive Biomarkers for Lesion After Transient Cerebral Ischemia

Rolf Gruetter, Hongxia Lei

Background and Purpose—Despite the improving imaging techniques, it remains challenging to predict the outcome early after transient cerebral ischemia. The aim of this study was thus to identify early metabolic biomarkers for outcome prediction. Methods—We ...

2011

In Vivo Evidence for Lactate as a Neuronal Energy Source

Pierre Magistretti, Renaud Jolivet

Cerebral energy metabolism is a highly compartmentalized and complex process in which transcellular trafficking of metabolites plays a pivotal role. Over the past decade, a role for lactate in fueling the energetic requirements of neurons has emerged. Furt ...

2011

Distinguishing drug-induced minor morphological changes from major cellular damage via label-free impedimetric toxicity screening

Philippe Renaud, Arnaud Bertsch, Robert Meissner, Sri Harsha Kasi Raj, Bilge Eker

We present a novel perfusion-based microfluidic platform for label-free drug toxicity screening which can single out non-lethal morphological changes from cellular death using electrical impedance spectroscopy. Minor cellular changes such as cell-cell cont ...

2011

Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction

Jeffrey Alan Hubbell

We present use of a synthetic, injectable matrix metalloproteinase (MMP)- responsive, bioactive hydrogel as an in situ forming scaffold to deliver thymosin beta 4 (T beta 4), a pro-angiogenic and pro-survival factor, along with vascular cells derived from ...

2011

The interplay between macrophages and angiogenesis in development, tissue injury and regeneration

Michele De Palma, Daniela Biziato

During organ development and remodeling, macrophages support angiogenesis, not only by secreting proangiogenic growth factors and matrix-remodeling proteases, but also by physically interacting with the sprouting vasculature to assist the formation of comp ...

2011

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search