Concept
Human evolutionary genetics
Publications associées (37)
Genetic features and genomic targets of human KRAB-zinc finger proteins
Didier Trono, Jacques Fellay, Priscilla Turelli, Christian Axel Wandall Thorball, Evaristo Jose Planet Letschert, Julien Léonard Duc, Romain Forey, Bara Khubieh, Sandra Eloise Kjeldsen, Alexandre Coudray, Michaël Imbeault, Cyril David Son-Tuyên Pulver, Jonas Caspar De Tribolet-Hardy
Krüppel-associated box (KRAB) domain-containing zinc finger proteins (KZFPs) are one of the largest groups of transcription factors encoded by tetrapods, with 378 members in human alone. KZFP genes are often grouped in clusters reflecting amplification by ...
2023Neural ADMIXTURE for rapid genomic clustering
Characterizing the genetic structure of large cohorts has become increasingly important as genetic studies extend to massive, increasingly diverse biobanks. Popular methods decompose individual genomes into fractional cluster assignments with each cluster ...
SPRINGERNATURE2023Mitochondrial Pseudogenes Suggest Repeated Inter-Species Hybridization among Direct Human Ancestors
The hypothesis that the evolution of humans involves hybridization between diverged species has been actively debated in recent years. We present the following novel evidence in support of this hypothesis: the analysis of nuclear pseudogenes of mtDNA ("NUM ...
MDPI2022Computational identification and experimental characterization of preferred downstream positions in human core promoters
Author summary Transcription of genes by the RNA polymerase II enzyme initiates at a genomic region termed the core promoter. The core promoter is a regulatory region that may contain diverse short DNA sequence motifs/elements that confer specific properti ...
PUBLIC LIBRARY SCIENCE2021First quantitative survey delineates the distribution of chimpanzees in the Eastern Central African Republic
Stéphane Joost, Estelle Rochat
Vast, pristine ecosystems and their biodiversity are vanishing globally at frightening speed, but many large tracts of wilderness have not yet been systematically inventoried and important natural populations of threatened species remain poorly characteriz ...
Elsevier2017Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses
Amalio Telenti, Danielle Thompson, Daniel Sauter, Jérémie Perreaud
Background: Known antiretroviral restriction factors are encoded by genes that are under positive selection pressure, induced during HIV-1 infection, up-regulated by interferons, and/or interact with viral proteins. To identify potential novel restriction ...
Biomed Central Ltd2015