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Publications associées (383)

Improved statistical evaluation of group differences in connectomes by screening-filtering strategy with application to study maturation of brain connections between childhood and adolescence

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Stephan Morgenthaler, David Paul Roger Romascano, Patric Hagmann, Djalel Eddine Meskaldji

Detecting local differences between groups of connectomes is a great challenge in neuroimaging, because the large number of tests that have to be performed and the impact on multiplicity correction. Any available information should be exploited to increase ...

Elsevier2015

Structure and Mechanism of the Influenza A M2(18-60) Dimer of Dimers

David Lyndon Emsley

We report a magic angle spinning (MAS) NMR structure of the drug-resistant S31N mutation of M2(18-60) from Influenza A. The protein was dispersed in diphytanoyl-sn-glycero-3-phosphocholine lipid bilayers, and the spectra and an extensive set of constraints ...

American Chemical Society2015

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization

Giovanni Dietler, Hilal Lashuel, Francesco Simone Ruggeri, Jae Sun Jeong, Raffaele Mezzenga

Amyloid fibrils associated with neurodegenerative diseases, such as Parkinson's and Alzheimer's, consist of insoluble aggregates of α-synuclein and Aβ-42 proteins with a high β-sheet content. The aggregation of both proteins occurs by misfolding of the mon ...

Wiley-Blackwell2015

Elephant Beer and Shinto Gates: Managing Similar Concepts in a Multilingual Database

Martin Benjamin

This paper addresses problems in equivalence among concepts, within and between languages. The Kamusi Project has begun building a massively multilingual dictionary that relates as many languages as possible for which data can be gathered. In the process, ...

2014

On Lock-Free Work-stealing Iterators for Parallel Data Structures

Martin Odersky, Aleksandar Prokopec, Dmytro Petrashko

With the rise of multicores, there is a trend of supporting data-parallel collection operations in general purpose programming languages. These operations are highly parametric, incurring abstraction performance penalties. Furthermore, data-parallel operat ...

2014

Mutable Checkpoint-Restart: Automating Live Update for Generic Server Programs

Calin Iorgulescu

The pressing demand to deploy software updates without stopping running programs has fostered much research on live update systems in the past decades. Prior solutions, however, either make strong assumptions on the nature of the update or require extensiv ...

ACM New York2014

Forge: Generating a High Performance DSL Implementation from a Declarative Specification

Martin Odersky, Tiark Rompf

Domain-specific languages provide a promising path to automatically compile high-level code to parallel, heterogeneous, and distributed hardware. However, in practice high performance DSLs still require considerable software expertise to develop and force ...

Assoc Computing Machinery2014

Spatial joins in main memory: implementation matters!

Darius Sidlauskas

A recent PVLDB paper reports on experimental analyses of ten spatial join techniques in main memory. We build on this comprehensive study to raise awareness of the fact that empirical running time performance findings in main-memory settings are results of ...

2014

Spores: A Type-Based Foundation for Closures in the Age of Concurrency and Distribution

Martin Odersky, Philipp Haller

Functional programming (FP) is regularly touted as the way forward for bringing parallel, concurrent, and distributed programming to the mainstream. The popularity of the rationale behind this viewpoint (immutable data transformed by function application) ...

2014

Statistics for brain connectomics revisited by two-step procedures

Dimitri Nestor Alice Van De Ville, Djalel Eddine Meskaldji

State-of-the-art neuroimaging data provides several ways today to construct "brain connectomics" based on structural and functional measures. Connection-wise statistical assessment suffers from the large amount of multiple comparisons and is suboptimal as ...

2014

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