Concept
Placentalia
Publications associées (14)
Species-specific regulation of XIST by the JPX/FTX orthologs
X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main trigger of XCI, is controlled in the mouse by an interplay of lncRNA genes (LRGs), some of which evolved concom ...
OXFORD UNIV PRESS2023A KRABsody for Embryo-Placental Development
Many of the hundreds of KRAB zinc finger proteins encoded by human and mouse are involved in taming the transcriptional regulatory potential of transposable elements. Reporting recently in Science, Yang et al. (2017) reveal that one murine family member, Z ...
2017DUX-family transcription factors regulate zygotic genome activation in placental mammals
Didier Trono, Evaristo Jose Planet Letschert, Julien Léonard Duc, Sonia Verp, Andrea Coluccio, Alberto De Iaco
In animal embryos, transcription is mostly silent for several cell divisions, until the release of the first major wave of embryonic transcripts through so-called zygotic genome activation (ZGA). Maternally provided ZGA-triggering factors have been identif ...
2017Mechanisms Underlying the Neuromodulation of Spinal Circuits for Correcting Gait and Balance Deficits after Spinal Cord Injury
Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Marco Capogrosso, Nikolaus Wenger, Emanuele Formento
Epidural electrical stimulation of lumbar segments facilitates standing and walking in animal models and humans with spinal cord injury. However, the mechanisms through which this neuromodulation therapy engages spinal circuits remain enigmatic. Using comp ...
Elsevier2016Kinematic and gait similarities between crawling human infants and other quadruped mammals
Auke Ijspeert, Ludovic Righetti
Crawling on hands and knees is an early pattern of human infant locomotion, which offers an interesting way of studying quadrupedalism in one of its simplest form. We investigate how crawling human infants compare to other quadruped mammals, especially pri ...
Frontiers Media Sa2015Inferring the Evolutionary History of Primate microRNA Binding Sites: Overcoming Motif Counting Biases
Jeffrey David Jensen, Feng Gao
The first microRNAs (miRNAs) were identified as essential, conserved regulators of gene expression, targeting the same genes across nearly all bilaterians. However, there are also prominent examples of conserved miRNAs whose functions appear to have shifte ...
Oxford Univ Press2014Is There a Need for Smooth Muscle Cell Transplantation in Urethral Reconstruction?
Background: Hypospadias and urethral strictures are conditions requiring additional tissue for reconstruction. Due to a limited source of tissue, autologous skin and oral mucosa are frequently used. However, long-term follow-up studies demonstrated signifi ...
Mary Ann Liebert, Inc2014The Channel-Activating Protease CAP1/Prss8 Is Required for Placental Labyrinth Maturation
Simona Frateschi, Friedrich Beermann, Roch-Philippe Charles, Aline Dousse
The serine protease CAP1/Prss8 is crucial for skin barrier function, lung alveolar fluid clearance and has been unveiled as diagnostic marker for specific cancer types. Here, we show that a constitutive knockout of CAP1/Prss8 leads to embryonic lethality. ...
Public Library of Science2013Embryonic stem cell potency fluctuates with endogenous retrovirus activity
Embryonic stem (ES) cells are derived from blastocyst-stage embryos and are thought to be functionally equivalent to the inner cell mass, which lacks the ability to produce all extraembryonic tissues. Here we identify a rare transient cell population withi ...
2012On the Relationship Between Protein-DNA Interactions and Circadian Gene Expression in Mouse Liver
Virtually every cell in our body tracks daily time using an endogenous mechanism called the circadian clock, which has a period of about 24 hours. This timing system offers a selective advantage by enabling organisms to anticipate periodic changes in envir ...
EPFL2011