Concept

Résistance vasculaire

Publications associées (127)

Processing of fluorescence angiograms for the quantification of vascular effects induced by anti-angiogenic agents in the CAM model

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska

The chicken embryo chorioallantoic membrane (CAM) is widely used as an in vivo model to study the vascular effects of angiogenesis modulating agents. The main goal of the present study was to develop and validate a quantitative method to characterize time- ...

Elsevier2010

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall

Tyler Nerton Thacher

Due to the pulsatile nature of blood flow, arteries are constantly exposed to dynamic mechanical forces; the pulsatility continuously stretches the vessel wall and the flow creates a frictional force on the interior surface. These stresses, referred to as ...

EPFL2009

Combination Therapy Using Verteporfin and Ranibizumab; Optimizing the Timing in the CAM Model

Hubert van den Bergh, Elodie Debefve

Combining photodynamic therapy (PDT) using verteporfin (Visudyne(R)) with ranibizumab (Lucentis(R)) can optimize the overall treatment outcome by providing more efficacy in vessel closure, and thus reduce the need for retreatment in patients with wet age-r ...

2009

RC time constant of single lung equals that of both lungs together: a study in chronic thromboembolic pulmonary hypertension

Nikolaos Stergiopoulos, Nico Westerhof

The product of resistance, R, and compliance, C (RC time), of the entire pulmonary circulation is constant. It is unknown if this constancy holds for individual lungs. We determined R and C in individual lungs in chronic thromboembolic pulmonary hypertensi ...

2009

Cell-responsive hydrogel for encapsulation of vascular cells

Jeffrey Alan Hubbell

The in vitro potential of a synthetic matrix metalloproteinase (MMP)-responsive poly(ethylene glycol) (PEG)-based hydrogel as a bioactive co-encapsulation system for vascular cells and a small bioactive peptide, thymosin beta 4 (T beta 4), was examined. We ...

2009

Coupling strategies for the numerical simulation of blood flow in deformable arteries by 3D and 1D models

Fabio Nobile

The fluid structure interaction mechanism in vascular dynamics can be described by either 3D or 1D models, depending on the level of detail of the flow and pressure patterns needed for analysis. A successful strategy that has been proposed in the past year ...

Elsevier2009

Intercellular calcium dynamics in smooth muscle cells

Dominique Seppey

Muscular arteries are able to actively modify their diameter by modulating the tone of the smooth muscle cells located within the arterial wall. A small variation of lumen diameter has a large influence on blood flow as well as on arterial pressure. The ca ...

EPFL2009

Autonomous effects of shear stress and cyclic circumferential stretch regarding endothelial dysfunction and oxidative stress: an ex vivo arterial model

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Paolo Silacci, Tyler Nerton Thacher

Cyclic circumferential stretch and shear stress caused by pulsatile blood flow work in concert, yet are very different stimuli capable of independently mediating endothelial function by modulating eNOS expression, oxidative stress (via production of supero ...

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

Design and validation of a telemetrically drived implantable glaucoma drainage device

Adan Villamarin

Glaucoma is one of the leading cause of irreversible blindness in the world and it usually occurs when the pressure inside the eyes gradually rises, permanently damaging the optic nerve. Medications and filtering surgery are two possible therapies availabl ...

2009

Stem cell-based cardiovascular tissue engineering

Thomas Krähenbühl

Cardiovascular diseases, including myocardial infarction, are the leading cause of death worldwide for both men and women. Current therapies are limited by the restricted intrinsic regeneration capacity of the heart and by the lack of organs for transplant ...

EPFL2009

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