This timeline lists notable events in the history of research into senescence or biological aging, including the research and development of life extension methods, brain aging delay methods and rejuvenation.
People have long been interested in making their lives longer and healthier. The most anсient Egyptian, Indian and Chinese books contain reasoning about aging. Ancient Egyptians used garlic in large quantities to extend their lifespan. Hippocrates (460-370 BC), in his Aphorisms, and Aristotle (384 – 322 BC), in On youth and old age, expressed their opinions about reasons for old age and gave advice about lifestyle. Medieval Persian physician Ibn Sina (980 – 1037), known in the West as Avicenna, summarized the achievements of earlier generations about this issue.
Descriptions of rejuvenation and immortality remedies are often found in the writings of alchemists. But all those remedies did not allow even alchemists themselves to live longer than a hundred years.
Though the average lifespan of people through the past millennia increased significantly, maximum lifespan almost did not change - even in ancient times there were fairly well and unbiasedly documented cases when some people lived for more than a hundred years (for example, Terentia who lived 103 or 104 years). While among the billions of people of the modern world, there is only one case of life over 120 years (Jeanne Calment, 122 years). The super-long lives of people that are mentioned in ancient books, apparently, are highly exaggerated, since archaeological data show that even the oldest of the ancient people lived no more than modern supercentenarians. In some cases the exaggeration, possibly, is not intentional but occurs due to errors in translation between languages and synchronization of chronological systems. The species limit of human life is estimated by scientists at 125–127 years, and even in the most ideal conditions a person will not live longer due to aging of the body.
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This course provides a comprehensive overview of the biology of cancer, illustrating the mechanisms that cancer cells use to grow and disseminate at the expense of normal tissues and organs.
The course covers in detail molecular mechanisms of cancer development with emphasis on cell cycle control, genome stability, oncogenes and tumor suppressor genes.
The anti-aging movement is a social movement devoted to eliminating or reversing aging, or reducing the effects of it. A substantial portion of the attention of the movement is on the possibilities for life extension, but there is also interest in techniques such as cosmetic surgery which ameliorate the effects of aging rather than delay or defeat it. There are many scientists of this movement with different approaches.
Following is a list of topics related to life extension: NOTOC ACE inhibitor Actuarial escape velocity Adenosine triphosphate (ATP) Advanced Cell Technology Corporation Aerobic exercise Age-adjusted life expectancy Ageless Age-Related Eye Disease Study Age-Related Macular Degeneration Aging Aging and memory Aging-associated diseases Aging brain Aging population Alcor Life Extension Foundation Alternative medicine American Aging Association American Academy of Anti-Aging Medicine (A4M) Amyloid Amyloid pl
Aubrey David Nicholas Jasper de Grey, né le à Londres, est un scientifique anglais, ancien informaticien à l’université de Cambridge et autodidacte en biogérontologie. Il vit en Californie depuis 2010. Inspiré de la « théorie mitochondriale du vieillissement » émise par le Denham Harman en 1972, il élabore le projet baptisé SENS. Cette théorie récapitule les causes du vieillissement, parmi lesquelles des radicaux libres, très réactifs, sous-produits de la transformation du glucose en ATP par les mitochondries.
Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging Drosophila. We c ...
AMER ASSOC ADVANCEMENT SCIENCE2023
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Background Accelerated epigenetic ageing can occur in untreated HIV infection and is partially reversible with effective antiretroviral therapy (ART). We aimed to make a long-term comparison of epigenetic ageing dynamics in people with HIV during untreated ...
Explore l'immortalité réplicative dans les cellules cancéreuses, en se concentrant sur l'érosion des télomères, l'activité de la télomérase et le rôle de la p53 dans le maintien de la stabilité génomique.
Explore la sénescence cellulaire, l'activation de l'oncogène, la réponse aux dommages à l'ADN et le dysfonctionnement des télomères dans les voies de suppression du cancer.
Predictive health assessment is of vital importance for smarter battery management to ensure optimal and safe operations and thus make the most use of battery life. This paper proposes a general framework for battery aging prognostics in order to provide t ...