Concept

P14arf

Publications associées (42)

Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale

Christian Heinis, Gerardo Turcatti, Julien Bortoli Chapalay, Alessandro Angelini, Manuel Leonardo Merz, Sevan Mleh Habeshian, Jonathan Patrice Vesin, Mischa Schüttel, Ganesh Kumar Mothukuri, Gontran Sangouard, Cristina Diaz Perlas, Zsolt Bognár

Macrocycles have excellent potential as therapeutics due to their ability to bind challenging targets. However, generating macrocycles against new targets is hindered by a lack of large macrocycle libraries for high-throughput screening. To overcome this, ...

2022

Genomic studies indicate a novel combination therapy for follicular lymphoma COMMENT

Elisa Oricchio

Follicular lymphoma (FL) is an incurable form of B-cell lymphoma. Genomic alterations that inactivate RB signaling are surprisingly common in indolent FL. We show that FLs that are positive for phosphorylated RB respond to dual CDK4/BCL2 inhibition. Our re ...

TAYLOR & FRANCIS INC2021

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression

Johan Auwerx

BACKGROUND & AIMS: SIRT5 plays pleiotropic roles via post-translational modifications, serving as a tumor suppressor, or an oncogene, in different tumors. However, the role SIRT5 plays in the initiation and progression of pancreatic ductal adenocarcinoma ( ...

W B SAUNDERS CO-ELSEVIER INC2021

Electrochemical detection of different p53 conformations by using nanostructured surfaces

Sandro Carrara, Francesca Stradolini, Sarah Tonello

Protein electrochemistry represents a powerful technique for investigating the function and structure of proteins. Currently available biochemical assays provide limited information related to the conformational state of proteins and high costs. This work ...

Springer2019

A set of microRNAs coordinately controls tumorigenesis, invasion, and metastasis

Douglas Hanahan, Mohammad Sadegh Saghafinia, Iacovos Michael

MicroRNA-mediated gene regulation has been implicated in various diseases, including cancer. This study examined the role of microRNAs (miRNAs) during tumorigenesis and malignant progression of pancreatic neuroendocrine tumors (PanNETs) in a genetically en ...

PNAS2019

The use of texture-based radiomics CT analysis to predict outcomes in early-stage non-small cell lung cancer treated with stereotactic ablative radiotherapy

Adrien Raphaël Depeursinge, Pierre Starkov

Objective: Stereotactic ablative radiotherapy (SABR) is being increasingly used as a non-invasive treatment for early-stage non-small cell lung cancer (NSCLC). A non-invasive method to estimate treatment outcomes in these patients would be valuable, especi ...

BRITISH INST RADIOLOGY2019

A bi-terminal protein ligation strategy to probe chromatin structure during DNA damage

Beat Fierz, Sinan Kilic, Iuliia Boichenko, Carolin Christine Lechner

The cellular response to DNA damage results in a signaling cascade that primes chromatin for repair. Combinatorial post-translational modifications (PTMs) play a key role in this process by altering the physical properties of chromatin and recruiting downs ...

2018

HIV-1 Vpr and p21 restrict LINE-1 mobility

Didier Trono, Priscilla Turelli, Flavia Marzetta

Long interspersed element-1 (LINE-1, L1) composes ∼17% of the human genome. However, genetic interactions between L1 and human immunodeficiency virus type 1 (HIV-1) remain poorly understood. In this study, we found that HIV-1 suppresses L1 retrotranspositi ...

2018

Fluorescent sensor proteins to assess the cellular uptake of therapeutic peptides and small molecules

Silvia Scarabelli

The determination of cell membrane permeability and of the absorption and clearance rates is an important step in the pharmacokinetic profiling of a new drug candidate. In a similar way, research in cell biology relies on the development of cell penetratin ...

EPFL2017

MATHICSE Technical Report : An online intrinsic stabilization strategy for the reduced basis approximation of parametrized advection-dominated problems

Alfio Quarteroni, Andrea Manzoni, Yvon Maday

We propose a new, black-box online stabilization strategy for reduced basis (RB) approx- imations of parameter-dependent advection-diffusion problems in the advection-dominated case. Our goal is to stabilize the RB problem irrespectively of the stabilizati ...

MATHICSE2016

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