Concept

Diabète gestationnel

Publications associées (99)

Spatial analysis of karst conduit networks and determination of parameters controlling the speleogenesis along preferential lithostratigraphic horizons

The main objective of this thesis is to improve the understanding of the position and characteristics of karst conduits within a rock massif. Such a characterisation is an important issue in civil engineering and in hydrogeology. Today in practice dissolut ...

EPFL2009

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

Johan Auwerx, Carlos Canto Alvarez

PURPOSE OF REVIEW: Peroxisome proliferator-activated receptor gamma coactivator-1-alpha (PGC-1alpha) has been extensively described as a master regulator of mitochondrial biogenesis. However, PGC-1alpha activity is not constant and can be finely tuned in r ...

2009

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

Rolf Gruetter, João Miguel das Neves Duarte

Type 1 diabetes can affect hippocampal function triggering cognitive impairment through unknown mechanisms. Caffeine consumption prevents hippocampal degeneration and memory dysfunction upon different insults and is also known to affect peripheral glucose ...

Wiley-Blackwell2009

Brain Surface Segmentation of Magnetic Resonance Images of the Fetus

Jean-Philippe Thiran, Meritxell Bach Cuadra, Marie Schaer, Dominique Zosso, Nawal Houhou, Damien Ferrario

In this work we present a method for the image analysis of Magnetic Resonance Imaging (MRI) of fetuses. Our goal is to segment the brain surface from multiple volumes (axial, coronal and sagittal acquisitions) of a fetus. To this end we propose a two-step ...

2008

Evaluation of glucose homeostasis

Johan Auwerx

Obesity and dyslipidemia are often found in association with insulin resistance (IR). These components combined with hypertension characterize the most common endocrine disorder in humans, the metabolic syndrome. Thus, in addition to profiling body weight ...

Wiley2007

Preventive and/or therapeutic agents for diabetes

Johan Auwerx

A preventive and/or therapeutic agent for diabetes, comprising a substance capable of inhibiting the activity of farnesoid X receptor as an active ingredient ...

2006

Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects

Johan Auwerx

CONTEXT: The type 2 iodothyronine deiodinase (D2) catalyzes the conversion of T(4) to the active form of thyroid hormone, which is a critical regulator of thermogenesis and glucose metabolism. A Thr92Ala polymorphism in the gene encoding D2 (DIO2) has been ...

2006

Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach

Didier Trono

AIMS/HYPOTHESIS: We examined a clinical model of ex vivo transdifferentiation of primary adult hepatocytes to insulin-secreting cells for the treatment of type 1 diabetes. MATERIALS AND METHODS: Isolated rat hepatocytes were transduced in primary culture w ...

Springer Verlag2006

Brain glucose concentrations in poorly controlled diabetes mellitus as measured by high-field magnetic resonance spectroscopy

Rolf Gruetter

Hyperglycemia and diabetes alter the function and metabolism of many tissues. The effect on the brain remains poorly defined, but some animal data suggest that chronic hyperglycemia reduces rates of brain glucose transport and/or metabolism. To address thi ...

Elsevier2005

Immunocytochemical expression of monocarboxylate transporters in the human visual cortex at midgestation

Pierre Magistretti, Maxime Olivier Baud, Luc Pellerin

Lactate and the other monocarboxylates are a major energy source for the developing brain. We investigated the immunocytochemical expression of two monocarboxylate transporters, MCT1 and MCT2, in the human visual cortex between 13 and 26 post-ovulatory wee ...

2004

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