Concept

SCN5A

Publications associées (12)

Computational pipeline to probe NaV1.7 gain-of-function variants in neuropathic painful syndromes

Applications of machine learning and graph theory techniques to neuroscience have witnessed an increased interest in the last decade due to the large data availability and unprecedented technology developments. Their employment to investigate the effect of ...

NATURE RESEARCH2020

Concealed abnormal atrial phenotype in patients with Brugada syndrome and no history of atrial fibrillation

Jean-Marc Vesin, Adrian Luca, Sasan Yazdani, Lukas Kappenberger

Objectives The electrocardiogram (ECG) of patients with BrS in sinus rhythm might reflect intrinsic atrial electrical abnormalities independent from any previous atrial fibrillation (AF). Aim of this study is to investigate the presence of P-wave abnormali ...

Elsevier2018

A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

Jeffrey David Jensen, Claudia Bank, Li Jiang

The therapeutic benefits of the neuraminidase (NA) inhibitor oseltamivir are dampened by the emergence of drug resistance mutations in influenza A virus (IAV). To investigate the mechanistic features that underlie resistance, we developed an approach to qu ...

Academic Press Ltd- Elsevier Science Ltd2016

Vertically stacked Si nanostructures for biosensing applications

Mihai Adrian Ionescu, Montserrat Fernandez-Bolanos Badia, Elizabeth Buitrago Godinez

High density (7-10 NW/μm) SiNW arrays of up to 16 nanowires vertically stacked with diameter widths below 20 nm have been successfully fabricated to create highly sensitive 3D FETs for biosensing applications. In order to take advantage of the increased se ...

Elsevier2012

Pressure drop modeling and comparisons with experiments for single- and two-phase sodium flow

Rakesh Chawla, Konstantin Mikityuk, Aurélia Chenu

The thermal-hydraulic code TRACE is currently being extended at the Paul Scherrer Institute (PSI) for enabling the study of sodium-cooled fast reactor (SFR) core behavior during transients in which boiling is anticipated. An accurate prediction of pressure ...

Elsevier2011

Single- and Two-Phase Flow Modeling for Coupled Neutronics/Thermal-Hydraulics Transient Analysis of Advanced Sodium-Cooled Fast Reactors

Aurélia Chenu

Nuclear power is nowadays in the front rank as regards helping to meet the growing worldwide energy demand while avoiding an excessive increase in greenhouse gas emissions. However, the operating nuclear power plants are mainly thermal-neutron reactors and ...

EPFL2011

A finite volume scheme for cardiac propagation in media with isotropic conductivities

Ricardo Esteban Ruiz Baier

A finite volume method for solving the monodomain and bidomain models for the electrical activity of myocardial tissue is presented. These models consist of a parabolic PDE and a system of a parabolic and an elliptic PDE, respectively, for certain electric ...

Elsevier2010

TRACE simulation of sodium boiling in pin bundle experiments under loss-of-flow conditions

Rakesh Chawla, Konstantin Mikityuk, Aurélia Chenu

In the framework of PSI's FAST code system, the thermal-hydraulic code TRACE is being extended for representation of sodium two-phase flow. As the currently available version (v.5) is limited to the simulation of only single-phase sodium flow, its applicab ...

Elsevier Science B.V.2009

A novel dominant mutation of the Na(v)1.4 alpha-subunit domain I leading to sodium channel myotonia

Background: Mutations in SCN4A may lead to myotonia. ...

2008

GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function

Friedrich Beermann

GLUT8 is a glucose transporter isoform expressed at high levels in testis; at intermediate levels in the brain, including the hippocampus; and at lower levels in the heart and several other tissues. GLUT8 is located in an intracellular compartment and does ...

2006

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