Concept

Clonazépam

Publications associées (8)

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Jocelin Grosse, Olivia Zanoletti, Marie-Isabelle Guillot de Suduiraut, Fiona Hollis, Michael van der Kooij, Ioannis Zalachoras, Laura Lozano Montes, Sonia Abad Florensa

Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...

Nature Publishing Group2018

GABA A receptors in the ventral tegmental area control the outcome of a social competition in rats

Maria del Carmen Sandi Perez, Michael van der Kooij, Ioannis Zalachoras

Social dominance can be attained through social competitions. Recent work in both humans and rodents has identified trait anxiety as a crucial predictor of social competitiveness. In addition, the anxiolytic GABAA positive modulator, diazepam, injected eit ...

2018

The motor systems of the mammalian brain are a remarkable product of many millions of years of evolution. It is the motor systems that make us and other mammals mobile, that guide our actions in response to sensory information and conversely modulate the v ...

EPFL2015

An Adeno-Associated Virus-Based Intracellular Sensor of Pathological Nuclear Factor-kappa B Activation for Disease-Inducible Gene Transfer

Elias Georges Gebara

Stimulation of resident cells by NF-kappa B activating cytokines is a central element of inflammatory and degenerative disorders of the central nervous system (CNS). This disease-mediated NF-kappa B activation could be used to drive transgene expression se ...

Public Library Science2013

Short-TE MRS has been proposed recently as a method for the in vivo detection and quantification of gamma-aminobutyric acid (GABA) in the human brain at 3 T. In this study, we investigated the accuracy and reproducibility of short-TE MRS measurements of GA ...

Wiley-Blackwell2013

Palladium-Catalyzed Domino Intramolecular N-Arylation/Intermolecular C-C Bond Formation for the Synthesis of Functionalized Benzodiazepinediones

Jieping Zhu

A divergent and regiocontrolled Pd-catalyzed domino sequence involving an intramol. N-arylation and an intermol. Heck reaction has been developed, providing rapid access to functionalized benzodiazepine-2,5-diones, e.g. I. The starting materials were synth ...

2008

Age of Himalayan bottom ice cores [2]

Jérôme Chappellaz

This paper is part of the special publication Gas hydrates: relevance to world margin stability and climatic change (eds J.P. Henriet and J. Mienert). The Antarctic and Greenland ice contains an almost direct record of past atmospheric CH 4. The record ove ...

Geological Society of London2004

Multiresolution Imaging of In Vivo Ligand-Receptor Interactions

Philippe Thévenaz

The aim of this study is to obtain voxel-by-voxel images of binding parameters between [11C]-Flumazenil and benzodiazepine receptors using positron emission tomography (PET). We estimate five local parameters (k1, k2, B'max, kon/VR, koff) by fitting a thre ...

SPIE2001

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