Concept

Exocytose

Publications associées (73)

Membrane trafficking in neurons regulated by new syntaxin 13-interacting proteins

Recently, it has been shown that correct trafficking of neuronal plasma membrane receptors along the endosomal pathway is directly implicated in molecular mechanisms underlying synaptic plasticity and is fundamental for proper neuronal communication. To un ...

EPFL2004

Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters

Steinunn Baekkeskov Hanahan

The GABA-synthesizing enzyme GAD65 is synthesized as a soluble cytosolic protein but undergoes post-translational modification(s) to become anchored to the cytosolic face of Golgi membranes before targeting to synaptic vesicle membranes in neuroendocrine c ...

Company of Biologists2004

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

Stewart Cole

The live tuberculosis vaccines Mycobacterium bovis BCG (bacille Calmette-Guérin) and Mycobacterium microti both lack the potent, secreted T-cell antigens ESAT-6 (6-kDa early secretory antigenic target) and CFP-10 (10-kDa culture filtrate protein). This is ...

2003

Morphological and molecular heterogeneity in release sites of single neurons

Harald Hirling, Juan-Carlos Sarria, Xin Wang

We have previously shown that labelling intensities for synaptic proteins vary strongly among synaptic boutons. Here we addressed the questions as to whether there are heterogeneous levels of integral membrane synaptic vesicle proteins at distinct active r ...

2003

Highly electrically insulating tethered lipid bilayers for probing the function of Ion channel proteins

Horst Vogel, Samuel Terrettaz, Michael Mayer

A method is presented to form gold-electrode-tethered lipid bilayers with exceptionally high elec. resistances. Elec. impedance spectroscopy is used to monitor the bilayer incorporation of a ligand-gated ion channel protein and the modulation of its channe ...

2003

Ligand Binding to G Protein-Coupled Receptors in Tethered Cell Membranes

Horst Vogel, Rudolf Hovius, Bruno Meyer

G protein-coupled receptors (GPCRs) constitute a large class of seven transmembrane proteins, which bind selectively agonists or antagonists with important consequences for cellular signaling and function. Comprehension of the mol. details of ligand bindin ...

2003

Overexpression of neuronal Sec1 enhances axonal branching in hippocampal neurons

Harald Hirling, Pascal Steiner, Juan-Carlos Sarria

The soluble N-ethylmaleimide-sensitive factor-attached protein receptor (SNARE) proteins syntaxin 1 and synaptosomal-associated protein-25 have been implicated in axonal outgrowth. Neuronal Sec1 (nSec1), also called murine unc18a (Munc18a), is a syntaxin 1 ...

2002

Developmental and spatial expression pattern of syntaxin 13 in the mouse central nervous system

Harald Hirling, Juan-Carlos Sarria

Vesicular transport involves SNARE (soluble- N-ethylmaleimide-sensitive-factor-attachment-protein-receptor) proteins on transport vesicles and on target membranes. Syntaxin 13 is a SNARE enriched in brain, associated with recycling endosomes; its overexpre ...

2002

Conversion of a transmembrane to a water-soluble protein complex by a single point mutation

Françoise Gisou van der Goot Grunberg

Proteins exist in one of two generally incompatible states: either membrane associated or soluble. Pore-forming proteins are exceptional because they are synthesized as a water-soluble molecule but end up being located in the membrane -- that is, they are ...

2002

Simultaneous arterial calcium dynamics and diameter measurements: application to myoendothelial communication

Nikolaos Stergiopoulos, Jean-Jacques Meister, Jean-Louis Bény, Alexander Schuster

The goal of the present study was to analyze the intercellular calcium communication between smooth muscle cells (SMCs) and endothelial cells (ECs) by simultaneously monitoring artery diameter and intracellular calcium concentration in a rat mesenteric art ...

2001

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