Récepteur sérotoninergique

Sciences sociales
Psychologie
Applied psychology
Psychologie clinique

Publications associées (22)

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X-ray structure of the mouse serotonin 5-HT3 receptor

Horst Vogel, Henning Paul-Julius Stahlberg, Rudolf Hovius, Cédric Deluz, Luigino Grasso, Romain Wyss, Menno Berend Tol, Ghérici Hassaïne

Neurotransmitter-gated ion channels of the Cys-loop receptor family mediate fast neurotransmission throughout the nervous system. The molecular processes of neurotransmitter binding, subsequent opening of the ion channel and ion permeation remain poorly un ...

Nature Publishing Group2014

Development of plasmid-based expression technology for rapid and sustained production of recombinant proteins in insect cells

Xiao Shen

Due to the high demand for heterogeneous protein production in insect cells, we have established efficient methods for plasmid-based transient gene expression (TGE) in various insect cell lines, including commonly used Spodoptera cell lines Sf9 and HighFiv ...

EPFL2014

Thermal Unfolding of a Mammalian Pentameric Ligand-gated Ion Channel Proceeds at Consecutive, Distinct Steps

Horst Vogel, Henning Paul-Julius Stahlberg, Cédric Deluz, Ghérici Hassaïne, Menno Berend Tol

Pentameric ligand-gated ion channels (LGICs) play an important role in fast synaptic signal transduction. Binding of agonists to the beta-sheet-structured extracellular domain opens an ion channel in the transmembrane alpha-helical region of the LGIC. How ...

Amer Soc Biochemistry Molecular Biology Inc2013

A Biochemical and Biophysical Investigation of 5-HT3 Receptor Stability

Menno Berend Tol

The 5-hydroxytryptamine 3 receptor (5-HT3R) is a member of the pentameric ligand-gated ion channel (pLGIC) family, that plays an important role in fast signal transduction and cell-cell communication in synapses: They convert a chemical signal from a neuro ...

EPFL2012

Functional consequences of prolactin signaling in endothelial cells: a potential link with angiogenesis in pathophysiology?

Patrycja Nowak-Sliwinska

Prolactin is best known as the polypeptide anterior pituitary hormone, which regulates the development of the mammary gland. However, it became clear over the last decade that prolactin contributes to a broad range of pathologies, including breast cancer. ...

2012

Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E

Rudolf Hovius

Since the first description of 5-HT3 receptors more than 50 years ago, there has been speculation about the molecular basis of their receptor heterogeneity. We have cloned the genes encoding novel 5-HT3 subunits 5-HT3C, 5-HT3D, and 5-HT3E and have shown th ...

Wiley-Blackwell2010

MicroPET imaging of 5-HT1A receptors in rat brain: a test-retest [F-18]MPPF study

Purpose Earlier studies have shown that positron emission tomography (PET) imaging with the radioligand [F-18] MPPF allows for measuring the binding potential of serotonin 5-hydroxytryptamine(1A) (5-HT1A) receptors in different regions of animal and human ...

Springer-Verlag2009

Characterization of the 5HT3 receptor in live cells and in vitro : heterologous expression, isolation and reconstitution in lipid membranes

Veronica Ponce de Leon

The serotonin type 3 receptor (5HT3R) is a homopentameric, cation selective channel that mediates fast excitatory transmission in the nervous system. It is a member of the Cys-loop family of receptors that include the nicotinic acetylcholine receptor (nACh ...

EPFL2009

Successive refinement for hypothesis testing and lossless one-helper problem

Jun Chen

We investigate two closely related successive refinement (SR) coding problems: 1) In the hypothesis testing (HT) problem, bivariate hypothesis H-o : P-XY against H-1 : P-X P-Y, i.e., test against independence is considered. One remote sensor collects data ...

2008

Repetitive Reversible Labeling of Proteins at Polyhistidine Sequences for Single-Molecule Imaging in Live Cells

Horst Vogel, Rudolf Hovius, Jean-Manuel Segura, Emmanuel Guignet

Sensitive live-cell fluorescence microscopy and single-molecule imaging are severely limited by rapid photobleaching of fluorescent probes. Herein, we show how to circumvent this problem using a novel, generic labeling strategy. Small nickel-nitrilotriacet ...

2007

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