Concept

Adult neurogenesis

Publications associées (165)

A Role For Adult Neurogenesis In Dentate Synaptic Plasticity Deficits And Memory Impairment In Down Syndrome

In the mammalian dentate gyrus (DG) neurogenesis continues throughout life. Accumulating evidence suggests a unique contribution of adult-generated neurons in DG synaptic plasticity and hippocampal-mediated learning and memory functions. However, the preci ...

2012

Lack of cyclin D2 impairing adult brain neurogenesis alters hippocampal-dependent behavioral tasks without reducing learning ability

Maria del Carmen Sandi Perez

The exact function of the adult brain neurogenesis remains elusive, although it has been suggested to play a role in learning and memory processes. In our studies, we employed cyclin D2 gene knockout (cD2 KO) mice showing impaired neurogenesis as well as d ...

2012

Psychobiological Vulnerability to Stress

Maria del Carmen Sandi Perez, Jorge Eduardo Castro Cifuentes

Several psychobiological factors are associated with vulnerability/resilience to stress-induced depression. Emerging evidence indicates behavioral traits, such as anxiety, can be related to depression-like symptoms after exposure to chronic stress. However ...

EPFL2012

A role for adult neurogenesis in dentate synaptic plasticity deficits and memory impairment in Down syndrome

Diego Ghezzi

The hippocampal dentate gyrus (DG) is one of the two sites where neurogenesis continues throughout life in the mammalian brain. Accumulating evidence suggests a unique contribution of adult-generated dentate neurons in hippocampal synaptic plasticity and h ...

2012

A Genetic Basis for Altered Sexual Behavior in Mutant Female Mice

Denis Duboule, Jozsef Zakany

Although neural substrates of mammalian female mating behavior have been described [1, 2], the association between complex courtship activity and specific underlying mechanisms remains elusive [3]. We have isolated a mouse line that unexpectedly shows alte ...

Elsevier2012

Morbillivirus Glycoprotein Expression Induces ER Stress, Alters Ca2+ Homeostasis and Results in the Release of Vasostatin

Harald Hirling, Jean-Marc Brunner

Although the pathology of Morbillivirus in the central nervous system (CNS) is well described, the molecular basis of neurodegenerative events still remains poorly understood. As a model to explore Morbillivirus-mediated CNS dysfunctions, we used canine di ...

Public Library of Science2012

Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits

Henry Markram, Felix Schürmann, Yun Wang, Imad Riachi

It is well-established that synapse formation involves highly selective chemospecific mechanisms, but how neuron arbors are positioned before synapse formation remains unclear. Using 3D reconstructions of 298 neocortical cells of different types (including ...

Natl Acad Sciences2012

Large-scale, high-resolution electrophysiological imaging of field potentials in brain slices with microelectronic multielectrode arrays

Diego Ghezzi, Luca Berdondini

Multielectrode arrays (MEAs) are extensively used for electrophysiological studies on brain slices, but the spatial resolution and field of recording of conventional arrays are limited by the low number of electrodes available. Here, we present a large-sca ...

Frontiers Research Foundation2012

Micro-engineering the Cerebral Cortical Cell Niche

Anja Kunze

A major problem in traditional cell culture methods, such as Petri dishes and culture flasks, is the very simplified artificial environment around the cells. Traditional cell culture methods lack features of the native cell niche, such as gradients and cel ...

EPFL2012

MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant

Didier Trono, Isabelle Barde, Sonia Verp, Johan Jakobsson

New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis i ...

Society for Neuroscience2012

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