Concept
Récepteur muscarinique
Publications associées (62)
Rules and mechanisms governing G protein coupling selectivity of GPCRs
Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui
G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: Gi/o, Gq, Gs, and G12/13. However, our understanding of the G protein selectivity of GPCRs is incomplet ...
Cambridge2023Mechanistic Understanding of Neurobehavioral Effects of Insecticides on the Larvae of Zebrafish (Danio rerio)
Due to conservation of neuronal functioning across phyla, molecular targets of insecticides are similar in insects and vertebrates. Insecticides thus pose a risk to aquatic vertebrates,such as fish, and potentially cause neurotoxic effects. Although these ...
EPFL2022Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing
Carl Petersen, Sylvain Crochet, Célia Roxane Gasselin, Benoît Hohl
Fast synaptic transmission relies upon the activation of ionotropic receptors by neurotransmitter release to evoke postsynaptic potentials. Glutamate and GABA play dominant roles in driving highly dynamic activity in synaptically connected neuronal circuit ...
CELL PRESS2021Accuracy of Molecular Simulation-Based Predictions of k(off) Values: A Metadynamics Study
Ursula Röthlisberger, Simone Meloni, Viacheslav Bolnykh, Michele Parrinello, Paolo Carloni
The k(off) values of ligands unbinding to proteins are key parameters for drug discovery. Their predictions based on molecular simulation may under- or overestimate experiment in a system- and/or technique-dependent way. Here we use an established method-i ...
AMER CHEMICAL SOC2020Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators
Gerardo Turcatti, Benjamin Rappaz, Fabien Kuttler, Damiano Banfi, Pierre Marquet, Pascal Jourdain
The ionotropic GABA(A) receptors represent the main target for different groups of widely used drugs having hypnotic and anxiolytic effects. So far, most approaches used to assess GABA activity involve invasive low -throughput electrophysiological techniqu ...
2019