Concept

Psychopathologie

Publications associées (24)

An energetic view of stress: Focus on mitochondria

Energy is required to sustain life and enable stress adaptation. At the cellular level, energy is largely derived from mitochondria – unique multifunctional organelles with their own genome. Four main elements connect mitochondria to stress: 1) Energy is r ...

2018

Stress, glucocorticoid receptor and social behaviors

Peripuberty, comprising childhood and adolescence, constitutes an important time window in the brain development and maturation. Exposure to prolonged stress during this period has been shown to increase the risk for the development of psychopathologies la ...

EPFL2017

Electroencephalogram (EEG) Frontal Asymmetry and Error-Related Signals Are Potential Markers of Internalizing and Externalizing Behaviors in Children: A Meta-Analysis

Michael Herzog, Ophélie Gladys Favrod

Objectives: The frontal hemispheric asymmetry and error-related components, as measured by EEG, are often considered to be biological correlates or “indicators of risk” for psychopathology. Here, we performed a meta-analysis to define specific patterns of ...

2017

Social isolation stress and chronic glutathione deficiency have a common effect on the glutamine-to-glutamate ratio and myo-inositol concentration in the mouse frontal cortex

Rolf Gruetter, João Miguel das Neves Duarte, Kim Do, Alberto Corcoba

Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative effects ...

Wiley-Blackwell2017

Rivastigmine decreases brain damage in HIV patients with mild cognitive deficits

David Paul Roger Romascano, Reto Meuli, Alessandro Daducci, Cristina Granziera, Djalel Eddine Meskaldji, Guillaume Bonnier, Ruslan Aydarkhanov, François Lazeyras

Rivastigmine has been shown to improve cognition in HIV+ patients with minor neurocognitive disorders; however, the mechanisms underlying such beneficial effect are currently unknown. To assess whether rivastigmine therapy is associated with decreased brai ...

Wiley2017

Isoform switching of steroid receptor co-activator-1 attenuates glucocorticoid-induced anxiogenic amygdala CRH expression

Maladaptive glucocorticoid effects contribute to stress-related psychopathology. The glucocorticoid receptor (GR) that mediates many of these effects uses multiple signaling pathways. We have tested the hypothesis that manipulation of downstream factors (' ...

Nature Publishing Group2016

Astrocytic beta(2)-adrenergic receptors mediate hippocampal long-term memory consolidation

Pierre Magistretti, Sylvain Eric Lengacher, Virginia Gao

Emotionally relevant experiences form strong and long-lasting memories by critically engaging the stress hormone/neurotransmitter noradrenaline, which mediates and modulates the consolidation of these memories. Noradrenaline acts through adrenergic recepto ...

National Academy of Sciences2016

The effects of stress during early postnatal periods on behavior and hippocampal neuroplasticity markers in adult male mice

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Michael van der Kooij

Infancy is a critical period for brain development. Emerging evidence indicates that stress experienced during that period can have long-term programming effects on the brain and behavior. However, whether different time periods represent different vulnera ...

2015

Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the amygdala

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Vandana Veenit

Stress during childhood and adolescence is a risk factor for psychopathology. Alterations in γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain, have been found following stress exposure and fear experiences and are often implica ...

Public Library of Science2014

CRHR1 links peripuberty stress with deficits in social and stress-coping behaviors

Maria del Carmen Sandi Perez, Orbicia Riccio Wicht, Vandana Veenit

Stressful life events during childhood and adolescence are important risk factors for the development of psychopathologies later in life. The corticotropin releasing hormone (CRH) and the CRH receptor 1 (CRHR1) have been implicated in the link between earl ...

Pergamon-Elsevier Science Ltd2014

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