Publications associées à Séquence consensus

Aleksandra Radenovic, Ke Liu, Jiandong Feng

Molecular sensing system including: a sensing device (5) comprising at least one support layer (10), and an active layer (6) mounted on said support layer and having at least one nano-pore (12) configured for translocation of a molecular analyte (18) there ...

2017

Large scale genomic reorganization of topological domains at the HoxD locus

Denis Duboule, Marion Leleu, Lucille Delisle, Daniël Noordermeer, Pierre Raymond Fabre, Leonardo Beccari, Benjamin Howard Mormann

BACKGROUND: The transcriptional activation of HoxD genes during mammalian limb development involves dynamic interactions with two topologically associating domains (TADs) flanking the HoxD cluster. In particular, the activation of the most posterior HoxD g ...

BioMed Central2017

Persona: A High-Performance Bioinformatics Framework

James Richard Larus, Edouard Bugnion, Christos Kozyrakis, Stuart Anthony Byma, Sam David Whitlock

Next-generation genome sequencing technology has reached a point at which it is becoming cost-effective to sequence all patients. Biobanks and researchers are faced with an oncoming deluge of genomic data, whose processing requires new and scalable bioinfo ...

2017

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

Denis Duboule, Jozsef Zakany, Guillaume Andrey, Leonardo Beccari, Anamaria Necsulea, Edgardo Rodriguez Carballo, Virginie Marcet

Vertebrate Hox genes encode transcription factors operating during the development of multiple organs and structures. However, the evolutionary mechanism underlying this remarkable pleiotropy remains to be fully understood. Here, we show that Hoxd8 and Hox ...

National Academy of Sciences2016

Influence of Rotational Nucleosome Positioning on Transcription Start Site Selection in Animal Promoters

Giovanna Ambrosini, Philipp Bucher, René Dreos

The recruitment of RNA-Pol-II to the transcription start site (TSS) is an important step in gene regulation in all organisms. Core promoter elements (CPE) are conserved sequence motifs that guide Pol-II to the TSS by interacting with specific transcription ...

Public Library Science2016

TEMPLE: analysing population genetic variation at transcription factor binding sites

Stefan Jean Laurent, Maria Litovchenko

Genetic variation occurring at the level of regulatory sequences can affect phenotypes and fitness in natural populations. This variation can be analysed in a population genetic framework to study how genetic drift and selection affect the evolution of the ...

Wiley-Blackwell2016

Integrating gene synthesis and microfluidic protein analysis for rapid protein engineering

Sebastian Maerkl, Bruno Emanuel Ferreira De Sousa Correia, Ekaterina Emilova Petrova, Matthew Christopher Blackburn

The capability to rapidly design proteins with novel functions will have a significant impact on medicine, biotechnology and synthetic biology. Synthetic genes are becoming a commodity, but integrated approaches have yet to be developed that take full adva ...

Oxford Univ Press2016

Analyzing ion distributions around DNA: sequence-dependence of potassium ion distributions from microsecond molecular dynamics

John Maddocks, Marco Pasi

Microsecond molecular dynamics simulations of B-DNA oligomers carried out in an aqueous environment with a physiological salt concentration enable us to perform a detailed analysis of how potassium ions interact with the double helix. The oligomers studied ...

Oxford University Press2015

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Séquence consensus

Molecular sensing device

Large scale genomic reorganization of topological domains at the HoxD locus

Persona: A High-Performance Bioinformatics Framework

Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

Influence of Rotational Nucleosome Positioning on Transcription Start Site Selection in Animal Promoters

TEMPLE: analysing population genetic variation at transcription factor binding sites

Integrating gene synthesis and microfluidic protein analysis for rapid protein engineering

Assessing Recent Selection and Functionality at Long Noncoding RNA Loci in the Mouse Genome

Analyzing ion distributions around DNA: sequence-dependence of potassium ion distributions from microsecond molecular dynamics

Graph Chatbot

Chattez avec Graph Search

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

Integrating gene synthesis and microfluidic protein analysis for rapid protein engineering

Analyzing ion distributions around DNA: sequence-dependence of potassium ion distributions from microsecond molecular dynamics

Assessing Recent Selection and Functionality at Long Noncoding RNA Loci in the Mouse Genome

Molecular sensing device

Influence of Rotational Nucleosome Positioning on Transcription Start Site Selection in Animal Promoters

Large scale genomic reorganization of topological domains at the HoxD locus

Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks

TEMPLE: analysing population genetic variation at transcription factor binding sites

Persona: A High-Performance Bioinformatics Framework