Publications associées à Flux (metabolism)

Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance

Rolf Gruetter, Hongxia Lei, Tian Cheng, Arnaud Comment, Josefina Adriana Maria Bastiaansen

BACKGROUND: The heart relies on continuous energy production and imbalances herein impair cardiac function directly. The tricarboxylic acid (TCA) cycle is the primary means of energy generation in the healthy myocardium, but direct noninvasive quantificati ...

Elsevier2015

A Study of Dynamic Responses of E. coli Metabolism Upon Large Perturbations Using Large-Scale Kinetic Models

Vassily Hatzimanikatis, Ljubisa Miskovic, Georgios Fengos, Milenko Tokic

In recent years, constraint-based approaches have been widely used for analyzing cellular metabolism. These approaches use stoichiometric models for the characterization of the intracellular fluxes at steady state. Nonetheless, the stoichiometric models la ...

2015

Data Repository for Automated Metabolomics Administration (DRAMA)

Joana Raquel Pinto Vieira, Pierre Guy Rémy Salvy

DRAMA framework was primarily developed with the purpose of facilitating data integration into genome scale models (GEM) of cellular metabolism. The existence of differently annotated genome scale models and metabolomics datasets that are provided without ...

2015

iSCHRUNK – in Silico Approach to Characterization and Reduction of Uncertainty in the Kinetic Models of Genome-scale Metabolic Networks

Vassily Hatzimanikatis, Ljubisa Miskovic, Stefano Andreozzi

Accurate determination of physiological states of cellular metabolism requires detailed information about metabolic fluxes, metabolite concentrations and distribution of enzyme states. Integration of fluxomics and metabolomics data, and thermodynamics-base ...

2015

Protein acetylation in metabolism-metabolites and cofactors

Johan Auwerx, Elena Katsyuba, Hongbo Zhang, Keir Joe Menzies

Reversible acetylation was initially described as an epigenetic mechanism regulating DNA accessibility. Since then, this process has emerged as a controller of histone and nonhistone acetylation that integrates key physiological processes such as metabolis ...

2015

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis

Vassily Hatzimanikatis, Stepan Tymoshenko, Rebecca Oppenheim, Jens Nielsen, Dominique Soldati-Favre

Toxoplasma gondii is a human pathogen prevalent worldwide that poses a challenging and unmet need for novel treatment of toxoplasmosis. Using a semi-automated reconstruction algorithm, we reconstructed a genome-scale metabolic model, ToxoNet1. The reconstr ...

Public Library Science2015

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Pierre Magistretti, Igor Allaman

The energy demands of the brain are high: they account for at least 20% of the body's energy consumption. Evolutionary studies indicate that the emergence of higher cognitive functions in humans is associated with an increased glucose utilization and expre ...

Elsevier2015

Systematic Reduction of Genome Scale Metabolic Reconstructions - redGEM

Vassily Hatzimanikatis, Meriç Ataman, Georgios Fengos, Keng Cher Soh, Daniel Federico Hernandez Gardiol

Genome-scale metabolic reconstructions (GEMs) are valuable resources for understanding and redesigning cellular networks as they encapsulate all the known biochemistry of the organisms from genes to proteins to their functions. Complexity of these large me ...

2015

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Flux (metabolism)

Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance

A Study of Dynamic Responses of E. coli Metabolism Upon Large Perturbations Using Large-Scale Kinetic Models

Data Repository for Automated Metabolomics Administration (DRAMA)

iSCHRUNK – in Silico Approach to Characterization and Reduction of Uncertainty in the Kinetic Models of Genome-scale Metabolic Networks

Computational Studies on Cellular Metabolism

Protein acetylation in metabolism-metabolites and cofactors

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis

Computational studies on Escherichia coli metabolism

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Systematic Reduction of Genome Scale Metabolic Reconstructions - redGEM

Graph Chatbot

Chattez avec Graph Search

Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis

Computational studies on Escherichia coli metabolism

Data Repository for Automated Metabolomics Administration (DRAMA)

A Study of Dynamic Responses of E. coli Metabolism Upon Large Perturbations Using Large-Scale Kinetic Models

Computational Studies on Cellular Metabolism

Systematic Reduction of Genome Scale Metabolic Reconstructions - redGEM

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

iSCHRUNK – in Silico Approach to Characterization and Reduction of Uncertainty in the Kinetic Models of Genome-scale Metabolic Networks

Protein acetylation in metabolism-metabolites and cofactors