Publications associées à Flux (metabolism)

Progress towards in vivo brain (13)C-MRS in mice: Metabolic flux analysis in small tissue volumes

The combination of dynamic (13)C MRS data under infusion of (13)C-labeled substrates and compartmental models of cerebral metabolism enabled in vivo measurement of metabolic fluxes with a quantitative and distinct determination of cellular-specific activit ...

Elsevier2017

Toward fully characterized knowledge gaps in metabolic networks: discovery of missing biochemistry in Escherichia coli

Vassily Hatzimanikatis, Meriç Ataman, Noushin Hadadi

Advances in medicine and biotechnology rely on the further understanding of biological processes. Despite the technological advances and increasing available types and amounts of omics data, significant biochemical knowledge gaps remain uncharacterised. We ...

2017

Mitochondrial Post-translational Modifications and Metabolic Control: Sirtuins and Beyond

Carlos Canto Alvarez

Introduction: In order to maintain metabolic homeostasis, organisms adjust the capacity and efficiency of ATP generation to changes in energetic demand and supply. While the transcriptional control of mitochondrial biogenesis allows to adapt mitochondrial ...

Bentham Science Publ Ltd2017

lumpGEM: Systematic generation of subnetworks and elementally balanced lumped reactions for the biosynthesis of target metabolites

Vassily Hatzimanikatis, Meriç Ataman

In the post-genomic era, Genome-scale metabolic networks (GEMs) have emerged as invaluable tools to understand metabolic capabilities of organisms. Different parts of these metabolic networks are defined as subsystems/pathways, which are sets of functional ...

2017

Integration of Metabolic, Regulatory and Signaling Networks Towards Analysis of Perturbation and Dynamic Responses

Vassily Hatzimanikatis, Meriç Ataman, Vikash Kumar Pandey

The expanding generation of dynamic biological data requires approaches that integrate and analyze information from different types of cellular processes –metabolism, regulation, and signaling–, and ultimately increase our insights into the cell behavior u ...

2017

Unlocking the full potential of kinetic metabolic models through characterization and reduction of uncertainty

Vassily Hatzimanikatis, Ljubisa Miskovic

Kinetic models are the most promising tool for comprehending the complex dynamic behavior of living cells. The primary goal of kinetic models is to capture the properties of the metabolic networks as a whole, and we need large-scale models for dependable i ...

2017

Facing The Unknown: Suggesting Alternative Novel Biochemistry in Escherichia coli and Saccharomyces cerevisiae

Vassily Hatzimanikatis, Meriç Ataman, Noushin Hadadi

While advances in genome sequencing have greatly facilitated the inference of metabolic networks, the presence of unknown biochemistry in the organisms still challenges the analysis and understanding of metabolism. Even for one of the most known organism l ...

2017

Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks

Vassily Hatzimanikatis, Meriç Ataman, Stepan Tymoshenko, Dominique Soldati-Favre

Novel antimalarial therapies are urgently needed for the fight against drug-resistant para- sites. The metabolism of malaria parasites in infected cells is an attractive source of drug targets but is rather complex. Computational methods can handle this co ...

Public Library of Science2017

Physiological Adaptations to Sugar Intake: New Paradigms from Drosophila melanogaster

Bruno Lemaitre, Wen Bin Chng

Sugars are important energy sources, but high sugar intake poses a metabolic challenge and leads to diseases. Drosophila melanogaster is a generalist fruit breeder that encounters high levels of dietary sugars in its natural habitat. Consequently, Drosophi ...

Elsevier2017

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Flux (metabolism)

Progress towards in vivo brain (13)C-MRS in mice: Metabolic flux analysis in small tissue volumes

Toward fully characterized knowledge gaps in metabolic networks: discovery of missing biochemistry in Escherichia coli

Mitochondrial Post-translational Modifications and Metabolic Control: Sirtuins and Beyond

lumpGEM: Systematic generation of subnetworks and elementally balanced lumped reactions for the biosynthesis of target metabolites

Integration of Metabolic, Regulatory and Signaling Networks Towards Analysis of Perturbation and Dynamic Responses

Unlocking the full potential of kinetic metabolic models through characterization and reduction of uncertainty

Facing The Unknown: Suggesting Alternative Novel Biochemistry in Escherichia coli and Saccharomyces cerevisiae

Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks

Physiological Adaptations to Sugar Intake: New Paradigms from Drosophila melanogaster

Hyperpolarized Magnetic Resonance Methods to Investigate Metabolic Pathways in Liver and Immune Cells

Graph Chatbot

Chattez avec Graph Search

Toward fully characterized knowledge gaps in metabolic networks: discovery of missing biochemistry in Escherichia coli

lumpGEM: Systematic generation of subnetworks and elementally balanced lumped reactions for the biosynthesis of target metabolites

Hyperpolarized Magnetic Resonance Methods to Investigate Metabolic Pathways in Liver and Immune Cells

Progress towards in vivo brain (13)C-MRS in mice: Metabolic flux analysis in small tissue volumes

Unlocking the full potential of kinetic metabolic models through characterization and reduction of uncertainty

Integration of Metabolic, Regulatory and Signaling Networks Towards Analysis of Perturbation and Dynamic Responses

Mitochondrial Post-translational Modifications and Metabolic Control: Sirtuins and Beyond

Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks

Physiological Adaptations to Sugar Intake: New Paradigms from Drosophila melanogaster

Facing The Unknown: Suggesting Alternative Novel Biochemistry in Escherichia coli and Saccharomyces cerevisiae