Concept
HapMap
Publications associées (34)
Biodiversity dynamics and the effect of urban environment on the distribution of genetic variation in the Geneva cross-border area
Stéphane Joost, Idris Guessous, Jens Ingensand, Estelle Rochat, Kevin Leempoel, Ivo Widmer, Alain Clémence
Population growth, urbanization and agriculture lead to degradation and loss of natural environment. This has an adverse effect on the diversity of habitats, species and genes and might cause decline in the quality of life of the resident population. In th ...
2015On Detecting Incomplete Soft or Hard Selective Sweeps Using Haplotype Structure
We present a new haplotype-based statistic (nS(L)) for detecting both soft and hard sweeps in population genomic data from a single population. We compare our new method with classic single-population haplotype and site frequency spectrum (SFS)-based metho ...
Oxford Univ Press2014The characterization of goat genetic diversity: Towards a genomic approach
Stéphane Joost, Pierre Taberlet
The investigation of genetic diversity at molecular level has been proposed as a valuable complement and sometimes proxy to phenotypic diversity of local breeds and is presently considered as one of the FAO priorities for breed characterization. By recomme ...
Elsevier2014Widespread Signals of Convergent Adaptation to High Altitude in Asia and America
Living at high altitude is one of the most difficult challenges that humans had to cope with during their evolution. Whereas several genomic studies have revealed some of the genetic bases of adaptations in Tibetan, Andean, and Ethiopian populations, relat ...
Cell Press2014Riding the whole-genome data tsunami: a landscape genomic study of local adaptation in Moroccan sheep and goats
Stéphane Joost, Sylvie Stucki, Kevin Leempoel
In Morocco, like in other developing countries, small ruminants play an important role in the livelihood of a large proportion of farmers and landless shepherds. Conserving traditional breeds is essential in these countries since they are able to prosper i ...
2014A systems approach to elucidate the genetic architecture of molecular phenotypes
A growing body of evidence suggests that changes in gene regulatory DNA are the major genetic determinants of variation in complex phenotypes; however, the underlying genes as well as cascades of intermediate molecular events remain in most cases elusive. ...
EPFL2014On the transition of genetic differentiation from isolation to panmixia: What we can learn from G(ST) and D
Population genetic differentiation characterizes the repartition of alleles among populations. It is commonly thought that genetic differentiation measures, such as G(ST) and D, should be near zero when allele frequencies are close to their expected value ...
Elsevier2014Visual backward masking deficits in schizophrenic patients are associated with polymorphisms in the nicotinic receptor alpha 7 subunit gene (CHRNA7)
Michael Herzog, Maya Roinishvili
Visual backward masking (BM) deficits are often proposed to be trait markers for schizophrenia, revealing the genetic underpinnings of the disease. Here, we show that masking deficits in the shine-through effect are associated with polymorphisms in the nic ...
2014Rounding Up Natural Gene Expression Variation during Development
Bart Deplancke, Sebastian Martin Waszak
Molecular insights into the genetic control of development have been mainly derived from single gene mutant studies. Francesconi and Lehner (2013) report now in Nature a genome-wide map of natural sequence variants that affect the temporal expression dynam ...
Elsevier2013Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls
Jacques Fellay, Amalio Telenti
Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have b ...
Public Library Science2013