Publications associées à Membre chiridien

The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes.

Denis Duboule, Lucille Delisle, Pierre Raymond Fabre, Leonardo Beccari, Edgardo Rodriguez Carballo

The mammalian HoxD cluster lies between two topologically associating domains (TADs) matching distinct enhancer-rich regulatory landscapes. During limb development, the telomeric TAD controls the early transcription of Hoxd genes in forearm cells, whereas ...

Cold Spring Harbor Laboratory Press2017

Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock

Denis Duboule

Collinear regulation of Hox genes in space and time has been an outstanding question ever since the initial work of Ed Lewis in 1978. Here we discuss recent advances in our understanding of this phenomenon in relation to novel concepts associated with larg ...

Cold Spring Harbor Laboratory Press2017

Control of growth and gut maturation by &ITHoxD&IT genes and the associated lncRNA &ITHaglr&IT

Denis Duboule, Jozsef Zakany, Fabrice Daniel Darbellay, Anamaria Necsulea

During embryonic development, Hox genes participate in the building of a functional digestive system in metazoans, and genetic conditions involving these genes lead to important, sometimes lethal,growth retardation. Recently, this phenotype was obtained af ...

Proceedings of the National Academy of Sciences2017

Large scale genomic reorganization of topological domains at the HoxD locus

Denis Duboule, Marion Leleu, Lucille Delisle, Daniël Noordermeer, Pierre Raymond Fabre, Leonardo Beccari, Benjamin Howard Mormann

BACKGROUND: The transcriptional activation of HoxD genes during mammalian limb development involves dynamic interactions with two topologically associating domains (TADs) flanking the HoxD cluster. In particular, the activation of the most posterior HoxD g ...

BioMed Central2017

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus

Denis Duboule, Leonardo Beccari, Anamaria Necsulea, Nicolas Lonfat, Edgardo Rodriguez Carballo, Nayuta Yakushiji

During vertebrate limb development, Hoxd genes are regulated following a bimodal strategy involving two topologically associating domains (TADs) located on either side of the gene cluster. These regulatory landscapes alternatively control different subsets ...

Cold Spring Harbor Laboratory2016

RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression

Nayuta Yakushiji

Polycomb group (PcG) proteins play a pivotal role in silencing developmental genes and help to maintain various stem and precursor cells and regulate their differentiation. PcG factors also regulate dynamic and complex regional specification, particularly ...

Company Of Biologists Ltd2016

Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan

Denis Duboule

Within land vertebrate species, snakes display extreme variations in their body plan, characterized by the absence of limbs and an elongated morphology. Such a particular interpretation of the basic vertebrate body architecture has often been associated wi ...

Elife Sciences Publications Ltd2016

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

Denis Duboule, Jozsef Zakany, Guillaume Andrey, Leonardo Beccari, Anamaria Necsulea, Edgardo Rodriguez Carballo, Virginie Marcet

Vertebrate Hox genes encode transcription factors operating during the development of multiple organs and structures. However, the evolutionary mechanism underlying this remarkable pleiotropy remains to be fully understood. Here, we show that Hoxd8 and Hox ...

National Academy of Sciences2016

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs

Denis Duboule, Guillaume Andrey, Dagmar Iber, Jing Liu

The large spectrum of limb morphologies reflects the wide evolutionary diversification of the basic pentadactyl pattern in tetrapods. In even-toed ungulates (artiodactyls, including cattle), limbs are adapted for running as a consequence of progressive red ...

Nature Publishing Group2014

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Membre chiridien

The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes.

Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock

Control of growth and gut maturation by &ITHoxD&IT genes and the associated lncRNA &ITHaglr&IT

Large scale genomic reorganization of topological domains at the HoxD locus

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus

RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression

Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs

Graph Chatbot

Chattez avec Graph Search

Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock

A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus

The HoxD cluster is a dynamic and resilient TAD boundary controlling the segregation of antagonistic regulatory landscapes.

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs

Large scale genomic reorganization of topological domains at the HoxD locus

Control of growth and gut maturation by &ITHoxD&IT genes and the associated lncRNA &ITHaglr&IT

Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan

Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape

ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm

RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression