Publications associées à Glutathion

Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents

Jérôme Waser, Christian Heinis, Gontran Sangouard, Elija Grinhagena

Easy access to a wide range of structurally diverse stapled peptides is crucial for the development of inhibitors of protein-protein interactions. Herein, we report bis-functional hypervalent iodine reagents for two-component cysteine-cysteine and cysteine ...

2021

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression

Johan Auwerx

BACKGROUND & AIMS: SIRT5 plays pleiotropic roles via post-translational modifications, serving as a tumor suppressor, or an oncogene, in different tumors. However, the role SIRT5 plays in the initiation and progression of pancreatic ductal adenocarcinoma ( ...

W B SAUNDERS CO-ELSEVIER INC2021

Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

Maria del Carmen Sandi Perez, Sarah Catherine Sonnay, Fiona Hollis, Pascal Steiner, Ioannis Zalachoras, Eva Ramos Fernandez, Laia Morato Fornaguera

The mammalian brain has high energy demands, which may become higher in response to environmental challenges such as psychogenic stress exposure. Therefore, efficient neutralization of reactive oxygen species that are produced as a by-product of ATP synthe ...

2020

MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients

Lijing Xin, Kim Do, Daniella Dwir, Basilio Giangreco

ious mechanisms involved in schizophrenia pathophysiology, such as dopamine dysregulation, glutamate/NMDA receptor dysfunction, neuroinflammation or redox imbalance, all appear to converge towards an oxidative stress "hub" affecting parvalbumine interneuro ...

2020

Biotransformation Capacity of Zebrafish (Danio rerio) Early Life Stages: Functionality of the Mercapturic Acid Pathway

Kristin Schirmer, Alena Tierbach

Zebrafish (Danio rerio) early life stages offer a versatile model system to study the efficacy and safety of drugs or other chemicals with regard to human and environmental health. This is because, aside from the well-characterized genome of zebrafish and ...

OXFORD UNIV PRESS2020

Disruption of redox homeostasis by enzymatic activation of a triakylphosphine probe in mitochondria

Pablo Rivera Fuentes, Jade Noémie Nam Nguyen

Redox homeostasis is essential for cell function and its disruption is assocd. with cancer, metabolic and neurodegenerative diseases. Redox balance is largely regulated by the relative concns. of reduced and oxidized glutathione. In eukaryotes, this ratio ...

2019

Manipulation of redox signaling in mitochondria with trialkylphosphine chemical probes

Pablo Rivera Fuentes

Subcellular organelles maintain distinct redox environments to carry out their normal physiol. functions. Disruption of redox homeostasis, either in the oxidative or reductive direction, is linked to disease. We recently showed that trialkylphosphine-based ...

American Chemical Society2019

N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study

Rolf Gruetter, Lijing Xin, Alessandra Griffa, Patric Hagmann, Kim Do, Emeline Mullier

Background: There is increasing evidence that redox dysregulation, which can lead to oxidative stress and eventually to impairment of oligodendrocytes and parvalbumin interneurons, may underlie brain connectivity alterations in schizophrenia. Accordingly, ...

Oxford University Press (OUP)2019

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Paul Joseph Dyson, Laure Menin, Wee Han Ang

Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents effective against a wide range of solid tumors. However, its use is restricted by side effects and/or by intrinsic or acquired drug resistance. Here, we ...

PNAS2019

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Glutathion

Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression

Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients

Role of glutathione S-transferases and the mercapturic acid pathway in the biotransformation potential of two zebrafish (Danio rerio) test systems: early life stages and PAC2 cells

Biotransformation Capacity of Zebrafish (Danio rerio) Early Life Stages: Functionality of the Mercapturic Acid Pathway

Disruption of redox homeostasis by enzymatic activation of a triakylphosphine probe in mitochondria

Manipulation of redox signaling in mitochondria with trialkylphosphine chemical probes

N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Graph Chatbot

Chattez avec Graph Search

Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression

Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents

Role of glutathione S-transferases and the mercapturic acid pathway in the biotransformation potential of two zebrafish (Danio rerio) test systems: early life stages and PAC2 cells

Manipulation of redox signaling in mitochondria with trialkylphosphine chemical probes

MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients

Disruption of redox homeostasis by enzymatic activation of a triakylphosphine probe in mitochondria

A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Biotransformation Capacity of Zebrafish (Danio rerio) Early Life Stages: Functionality of the Mercapturic Acid Pathway

N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study