Concept
Déshydrogénase
Publications associées (38)
The role of nicotinamide riboside metabolism in pancreatic beta cells
Pancreatic beta cells play a major role in the regulation of glucose homeostasis by secreting insulin in response to elevated blood glucose levels. A gradual deterioration of functional beta cell mass and the chronic elevation of blood glucose levels are c ...
EPFL2022Tailored extracellular electron transfer pathways enhance the electroactivity of Escherichia coli
Ardemis Anoush Boghossian, Melania Reggente, Mohammed Mouhib, Nils Schürgers, Lin Li
Extracellular electron transfer (EET) engineering in Escherichia coli holds great potential for bioremediation, energy and electrosynthesis applications fueled by readily available organic substrates. Due to its vast metabolic capabilities and availability ...
20213D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme
Glutamate dehydrogenases (GDHs) are widespread metabolic enzymes that play key roles in nitrogen homeostasis. Large glutamate dehydrogenases composed of 180kDa subunits (L-GDHs(180)) contain long N- and C-terminal segments flanking the catalytic core. Desp ...
2021SLC25A51 is a mammalian mitochondrial NAD(+) transporter
Mitochondria require nicotinamide adenine dinucleotide (NAD(+)) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD(+) transporters have been identified in yeast and plants(1,2), but thei ...
NATURE RESEARCH2020Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans
Rolf Gruetter, Lijing Xin, Özlem Ipek, Maya Shevlyakova
The brain requires a large amount of energy, mostly derived from the metabolism of glucose, which decreases substantially with age and neurological diseases. While mounting evidence in model organisms illustrates the central role of brain nicotinamide aden ...
FRONTIERS MEDIA SA2020