Concept

Glycoprotein 130

Publications associées (5)

Unpaired extracellular cysteine mutations of CSF3R mediate gain or loss of function

Exclusive of membrane-proximal mutations seen commonly in chronic neutrophilic leukemia (e.g. T618I), functionally defective mutations in the extracellular domain of the granulocyte colony-stimulating factor receptor (CSF3R) have been reported only in seve ...

American Association for Cancer Research2017

Gene expression analysis of metastases and IL-1R1 characterization in a NALP3 mouse model

Heidi Fournier

Tumor microenvironment contributes strongly to tumor evolution toward metastasis, a final stage in cancer progression. It provides essential clues to promote migration of cancer cells in metastatic sites. Moreover, inflammatory cells and immunomodulatory m ...

2011

Modulation of Dendritic Cells Function by H. polygyrus Products

Blaise Dayer

Dendritic cells (DCs) are crucial antigen-presenting cells that can drastically change the development of an immune response by polarising T helper cells toward a Th1 or a Th2 phenotype. Heligmosomoides polygyrus, a murine model of human helminth, has been ...

2011

Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome

Patrick Aebischer, Jean-Charles Bensadoun

Ciliary neurotrophic factor prevents behavioural deficits and striatal degeneration in rat and primate models of Huntington's disease. Interleukin- 6, another member of the cytokine family, and the chimeric molecule (IL6/IL6R) in which interleukin-6 and it ...

2001

Antibodies which bind the G-CSF receptor extracelluar domain and methods of treatment

Andrew Charles Oates

PCT No. PCT/US95/01696 Sec. 371 Date Jan. 21, 1997 Sec. 102(e) Date Jan. 21, 1997 PCT Filed Feb. 8, 1995 PCT Pub. No. WO95/21864 PCT Pub. Date Aug. 17, 1995The invention relates to a composition comprising antibodies or binding portions thereof which bind ...

1999

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