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Publications associées (7)

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau

Hilal Lashuel, Nadine Aït Bouziad, Anass Chiki, Galina Limorenko

The microtubule-associated protein Tau is implicated in the pathogenesis of several neurodegenerative disorders, including Alzheimer's disease. Increasing evidence suggests that post-translational modifications play critical roles in regulating Tau's norma ...

2020

Development of novel methods and tools to decipher the huntingtin post-translation modifications code

Anass Chiki

Huntington's disease (HD) is a fatal genetic neurodegenerative disorder caused by a CAG repeat expansion in the Huntingtin gene of more than 36 repeats. This repeat is translated into a polyglutamine (polyQ) stretch within the first exon-encoded region of ...

EPFL2020

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

Hilal Lashuel, Jonathan Jean-Pierre Ricci, Anass Chiki, Andreas Reif

Huntington’s Disease (HD) is an inherited fatal neurodegenerative disease caused by a CAG expansion (36) in the first exon of the HD gene, resulting in the expression of the Huntingtin protein (Htt) or N-terminal fragments thereof with an expanded polygl ...

2018

Resonance Light Scattering in Dye-Aggregates Forming in Dewetting Droplets

Roland Hany, Jakob Heier, Gian-Luca Bona, Raffaele Mezzenga

Small organic semiconducting molecules assembling into supramolecular J- and H- aggregates have attracted much attention due to outstanding optoelectronic properties. However, their easy and reproducible fabrication is not yet sufficiently developed for in ...

American Chemical Society2014

EARLY-ONSET DYSFUNCTION OF RETROSPLENIAL CORTEX PRECEDES OVERT AMYLOID PLAQUE FORMATION IN Tg2576 MICE

Guillaume Poirier

A mouse model of amyloid pathology was used to first examine using a cross sectional design changes in retrosplenial cortex activity in transgenic mice aged 5, 11, 17, and 23 months. Attention focused on: (1) overt amyloid labeled with beta-amyloid((1-42)) ...

2011

Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis

Hilal Lashuel, Adrian Schmid, Richard Alan Mimna, Karine Murat, Marie-Stéphanie Camus, Jérémy Bérard

The study of conformational transitions of peptides has obtained considerable attention recently because of their importance as a mol. key event in a variety of degenerative diseases. However, the study of peptide self-assembly into beta-sheets and amyloid ...

2007

"Switch peptides"

Lydiane Jeanine Saucède

Despite of considerable progress in the research at the interface of Chemistry, Biology and Medicine, neurodegenerative diseases affect more and more seriously our ageing population and remain a real therapeutic challenge for researcher. Nevertheless, adva ...

EPFL2006

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