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The understanding of dynamic metabolic regulations is important for physiol. studies and strain characterization tasks. The present study combined transient expts. with online metabolic flux anal. (MFA) in order to quantify metabolic regulations, namely ca ...
14-3-3 proteins are phosphoserine/threonine-binding proteins that play important roles in many regulatory processes, including intracellular protein targeting. 14-3-3 proteins can anchor target proteins in the cytoplasm and in the nucleus or can mediate th ...
Localized 13C nuclear magnetic resonance (NMR) spectroscopy provides a unique window for studying cerebral carbohydrate metabolism through, e.g. the completely non-invasive measurement of cerebral glucose and glycogen metabolism. In addition, label incorpo ...
The identification of phosphorylation sites in proteins provides a powerful tool to study signal transduction pathways and to establish interaction networks involving signaling elements. Using different strategies to identify phosphorylated residues, we re ...
Recent structural data suggest that the number of identical subunits (c or III) assembled into the cation-powered rotor of F1F0 ATP synthase depends on the biological origin. Atomic force microscopy allowed individual subunits of the cylindrical transmembr ...
Despite striking advances in functional brain imaging, the cellular and molecular mechanisms that underlie the signals detected by these techniques are still largely unknown. The basic physiological principle of functional imaging is represented by the tig ...
Synthesis of adenosine triphosphate (ATP) by the F1F0 ATP synthase involves a membrane-embedded rotary engine, the F-0 domain, which drives the extra-membranous catalytic F-1 domain. The F-0 domain consists of subunits a(1)b(2) and a cylindrical rotor asse ...
CCAAT/enhancer-binding protein (C/EBP) family members are transcription factors involved in important physiological processes, such as cellular proliferation and differentiation, regulation of energy homeostasis, inflammation, and hematopoiesis. Transcript ...
Electrophilically induced cyclic acetal formation of the O-benzyl dipeptide esters Fmoc-NMeIle-Thr-OBn (1) and of Fmoc-Pro-Thr-OBn (6) has been observed to lead predominantly to the (R) diastereomers 2b and 8b at the 2-C position of the resulting substitut ...
The isolation and sepn. of the mol. variants of monoclonal IgA from cell culture supernatants is possible using several filtration and ion-exchange chromatog. steps, followed by size-exclusion chromatog. for the actual sepn. of the mol. variants. The latte ...
