Concept
Inositol
Publications associées (21)
Social isolation stress and chronic glutathione deficiency have a common effect on the glutamine-to-glutamate ratio and myo-inositol concentration in the mouse frontal cortex
Rolf Gruetter, Kim Do, João Miguel das Neves Duarte, Alberto Corcoba
Environmental stress can interact with genetic predisposition to increase the risk of developing psychopathology. In this work, we tested the hypothesis that social isolation stress interacts with impaired glutathione synthesis and have cumulative effects ...
Wiley-Blackwell2017N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development
Rolf Gruetter, Kim Do, João Miguel das Neves Duarte
Background: Glutathione (GSH) is the major cellular redox-regulator and antioxidant. Redox-imbalance due to genetically impaired GSH synthesis is among the risk factors for schizophrenia. Here we used a mouse model with chronic GSH deficit induced by knock ...
2012Biophysical Basis of the Diffusion-Weighted Magnetic Resonance Signal in the Rat Brain
Nuclear magnetic resonance (NMR) can be used in-vivo in a vast array of applications, such as anatomical imaging (magnetic resonance imaging, MRI), localized chemical composition characterization (magnetic resonance spectroscopy, MRS), cellular structure a ...
EPFL2010Neurochemical profile of the developing mouse cortex determined by in vivo1H NMR spectroscopy at 14.1 T and the effect of recurrent anaesthesia
Rolf Gruetter, Kim Do, João Miguel das Neves Duarte
P>The neurochemical profile of the cortex develops in a region and time specific manner, which can be distorted by psychiatric and other neurological pathologies. Pre-clinical studies often involve experimental mouse models. In this study, we determined th ...
Wiley-Blackwell2010In vivo H-1 NMR measurement of glycine in rat brain at 9.4 T at short echo time
Rolf Gruetter, Lijing Xin, Giulio Gambarota, Chiara Perazzolo
Glycine is an amino acid present in mammalian brain, where it acts as an inhibitory and excitatory neurotransmitter. The two detectable protons of glycine give rise to a singlet at 3.55 ppm that overlaps with the more intense myo-inositol resonances, and i ...
Wiley-Blackwell2008