Technetium (99mTc) sestamibi

DISPLAYTITLE:Technetium (99mTc) sestamibi Technetium (99mTc) sestamibi (INN) (commonly sestamibi; USP: technetium Tc 99m sestamibi; trade name Cardiolite) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six (sesta=6) methoxyisobutylisonitrile (MIBI) ligands. The anion is not defined. The generic drug became available late September 2008. A scan of a patient using MIBI is commonly known as a "MIBI scan". Sestamibi is taken up by tissues with large numbers of mitochondria and negative plasma membrane potentials. Sestamibi is mainly used to image the myocardium (heart muscle). It is also used in the work-up of primary hyperparathyroidism to identify parathyroid adenomas, for radioguided surgery of the parathyroid and in the work-up of possible breast cancer. Myocardial perfusion imaging A MIBI scan or sestamibi scan is now a common method of cardiac imaging. Technetium (99mTc) sestamibi is a lipophilic cation which, when injected intravenously into a patient, distributes in the myocardium proportionally to the myocardial blood flow. Single photon emission computed tomography (SPECT) imaging of the heart is performed using a gamma camera to detect the gamma rays emitted by the technetium-99m as it decays. Two sets of images are acquired. For one set, 99mTc MIBI is injected while the patient is at rest and then the myocardium is imaged. In the second set, the patient is stressed either by exercising on a treadmill or pharmacologically. The drug is injected at peak stress and then imaging is performed. The resulting two sets of images are compared with each other to distinguish ischemic from infarcted areas of the myocardium. This imaging technique has a sensitivity of around 90%. Resting images are useful only for detecting tissue damage, while stress images will also provide evidence of coronary artery (ischemia) disease. When combined with the drug dipyridamole, a brand name of which is Persantine, a MIBI scan is often referred to as a Persantine MIBI scan.

À propos de ce résultat

Cette page est générée automatiquement et peut contenir des informations qui ne sont pas correctes, complètes, à jour ou pertinentes par rapport à votre recherche. Il en va de même pour toutes les autres pages de ce site. Veillez à vérifier les informations auprès des sources officielles de l'EPFL.

Publications associées (7)

Unités associées (2)

Concepts associés (4)

Cours associés (2)

Séances de cours associées (2)

PHYS-770: CIBM translational MR neuroimaging & spectroscopy

Magnetic resonance imaging (MRI) and spectroscopy (MRS) will be addressed in detail, along with experimental design, data gathering and processing on MRS, structural and functional MRI in humans and r

PHYS-760: CIBM translational MR neuroimaging & spectroscopy

Scintigraphie

La scintigraphie est une méthode d' de médecine nucléaire qui produit une image fonctionnelle par l'administration d'un médicament radiopharmaceutique (MRP) dont on détecte les rayonnements une fois qu'il a été capté par l'organe ou la cible à examiner. Le patient reçoit des molécules ou des isotopes radioactifs qui vont se fixer sur les organes ou les tissus que l'on cherche à explorer. Ensuite, une machine, en général une gamma-caméra, détecte les rayons émis par le corps. Enfin, on reconstruit l'image obtenue.

Gamma camera

A gamma camera (γ-camera), also called a scintillation camera or Anger camera, is a device used to image gamma radiation emitting radioisotopes, a technique known as scintigraphy. The applications of scintigraphy include early drug development and nuclear medical imaging to view and analyse images of the human body or the distribution of medically injected, inhaled, or ingested radionuclides emitting gamma rays. Scintigraphy ("scint") is the use of gamma cameras to capture emitted radiation from internal radioisotopes to create two-dimensional images.

Tomographie par émission monophotonique

vignette|droite|Image dans le plan axial du cerveau obtenue par tomographie d'émission monophotonique utilisant le Tc-99. La tomographie par émission monophotonique, en abrégé TEMP, ou même SPECT (de l'Single photon emission computed tomography), aussi appelée tomoscintigraphie par émission monophotonique, est une technique qui repose sur le principe de la scintigraphie et qui permet d'effectuer des images ainsi que des reconstructions en trois dimensions d'organes et de leur métabolisme à l'aide d'un ensemble de gamma caméras tournant autour du patient.

A Handheld Probe for beta(+)-Emitting Radiotracer Detection in Surgery, Biopsy and Medical Diagnostics based on Silicon Photomultipliers

Edoardo Charbon, Claudio Bruschini, Christian Mester

We present a new, handheld probe for radiotracer detection in vivo and inside operating theatres, where PET scanners cannot be used for radioguided surgery. The device is based on scintillation detectors optically coupled to Silicon Photomultipliers (SiPMs ...

Ieee2011

Reactivity of manganese, technetium and rhenium aquacarbonyl-complexes as potential precursors for radiopharmaceuticals

Pascal Grundler

Technetium is an artificial element and its isotope 99mTc is now used for several years as radio-imaging agent. Much research effort is directed towards enhanced targeting of the imaging agents in order to improve accuracy of the diagnosis and reduce the r ...

EPFL2005

Improvement in the Quantification of Myocardial Perfusion Using an Automatic Spline-Based Registration Algorithm

Philippe Thévenaz

Purpose: To improve the quantification of myocardial perfusion by registering the time series of magnetic resonance (MR) images with injection of gadolinium. Materials and Methods: Eight patients underwent MR scans to perform myocardial perfusion exam. Two ...

Wiley-Liss, Inc.2003

Détecteurs de rayons X et gamma EE-536: Physical models for micro and nanosystems

Explore les appareils d'imagerie à rayons X et gamma, les détecteurs de semi-conducteurs et les applications de transport de charge dans les détecteurs.

Détecteurs de gamma et de rayons X EE-536: Physical models for micro and nanosystems

Explore les appareils d'imagerie à rayons X et gamma, les types de détecteurs, la résolution d'énergie et les mécanismes de transport de charge.