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Genetic hearing loss accounts for up to 50% of prelingual deafness worldwide, yet there are no biologic treatments currently available. To investigate gene therapy as a potential biologic strategy for restoration of auditory function in patients with genet ...
American Association for the Advancement of Science2015
Dicationic ruthenium(II)-p-cymene complexes containing curcumin ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and ionic N-methyl-1,3,5-triaza-7-phosphaadamantane [PTA-Me]X (X = BF4 or I) have been synthesized and fully characterized for the fi ...
Over the course of a 4-day period of metamorphosis, the Drosophila larval nervous system is remodeled to prepare for adult-specific behaviors. One example is the reorganization of peripheral nerves in the abdomen, where five pairs of abdominal nerves (A4-A ...
We present a python implementation of the implicit level set algorithm to model propagation of planar hydraulic fractures. This algorithm was first introduced by Peirce & Detournay in (2008). The growth of a fluid driven planar fracture is modelled by coup ...
In vertebrate development, the sequential and rhythmic segmentation of the body axis is regulated by a "segmentation clock". This clock is comprised of a population of coordinated oscillating cells that together produce rhythmic gene expression patterns in ...
Introduction: As otology enters the field of gene therapy and human studies commence, the question arises whether audiograms - the current gold standard for the evaluation of hearing function - can consistently predict cellular damage within the human inne ...
Droplet‐based microfluidics allows the generation and manipulation of many independent microreactors (pico‐ to nanoliter volumes) optionally hosting human cells. However, one limitation is that mammalian cells within droplets are not fully accessible from ...
Out-of-body experiences (OBEs) are illusory perceptions of one's body from an elevated disembodied perspective. Recent theories postulate a double disintegration process in the personal (visual, proprioceptive and tactile disintegration) and extrapersonal ...
The vestibular organs are very important to generate reflexes critical for stabilizing gaze and body posture. Vestibular diseases significantly reduce the quality of life of people who are affected by them. Some research groups have recently started develo ...
The SNR spectrum was previously introduced as a natural consequence of using cepstral normalisa-
tion in speech recognition; it is closely related to the articulation index of Fletcher. Motivated initially
by a theoretical difficulty in frequency warping, ...