Concept
Malaria prophylaxis
Publications associées (57)
Stopping malaria parasites dead in their tracks
The search for new antimalarial strategies takes a step forward with the discovery of a small parasitocidal molecule that inhibits a calcium-dependent protein kinase and may thereby interfere with parasite motility ...
Nature Publishing Group2008Protein kinases of malaria parasites: an update
Protein kinases (PKs) play crucial roles in the control of proliferation and differentiation in eukaryotic cells. Research on protein phosphorylation has expanded tremendously in the past few years, in part as a consequence of the realization that PKs repr ...
Elsevier2008Alisiaquinones and alisiaquinol, dual inhibitors of Plasmodium falciparum enzyme targets from a New Caledonian deep water sponge
Four new meroterpenes, alisiaquinones A-C (1-3) and alisiaquinol (4), were isolated from a New Caledonian deep water sponge. Their structures and relative stereochemistry were elucidated by spectroscopic data analysis. They are related to xestoquinone, but ...
American Chemical Society2008Pbcrk-1, the Plasmodium berghei orthologue of P. falciparum cdc-2 related kinase-1 (Pfcrk-1), is essential for completion of the intraerythrocytic asexual cycle
The molecular mechanisms underlying gametocytogenesis in malaria parasites are not understood. Plasmodium falciparum cdc2-related kinase 1 (pfcrk-1), a gene that is expressed predominantly in gametocytes, bears homology to the PITSLRE subfamily of cyclin-d ...
Elsevier2006