Gabú Region is the easternmost region in Guinea-Bissau. Its capital is Gabú. The region borders Senegal to the north, Guinea to the east and south and the Guinea-Bissau regions of Tombali and Bafatá to the west. It covers an area of 9,150 km2, making it the largest of Guinea-Bissau's administrative regions. It is an inland region covered with savannah or light savannah woodland and receives an annual rainfall of more than .
As of 2009, the total population of the region was 205,608, with the urban population being 51,211 and rural being 154,397. The sex ratio of the region is 94 females for every hundred males. As of 2009, the net activity rate was 72.44 per cent, proportion of employed labour force was 43.86 per cent, proportion of labour force was 74.48 and the proportion of potentially active population was 43.86 per cent. The absolute poverty rate, people earning less than $2 a day, in the region stood at 72.4 per cent, with a regional contribution of 13.6 per cent to the national poverty totals.
Gabu is an inland region and the highest point is Monte Torin with an elevation of . The internal region has plains, which are interspersed with rias. There are lot of meandering rivers, many of them forming estuaries in the coastal regions. The principal river, Corubal River, flows through the region. The climate is hot and tropical and the region has two seasons. The onset of summer is from December to May with April - May period having temperature ranges from to . The rainy season is usually from May to November. The region receives an average rainfall of around compared to the coastal regions, which receive . The internal regions are covered with Savannah or light Savannah woodland.
Gabú is divided into 5 sectors, namely, Boé, Gabú, Piche, Pirada and Sonaco. Guinea-Bissau got independence from Portugal on 24 September 1973 after wars and diplomatic political actions under the Partido Africano da Independência de Cabo Verde (PAICV), while Portugal accepted the independence of Cape Verde on 5 July 1975.