Publications associées à Excipient

From Surfactants to Viscoelastic Capsules

Esther Amstad, Gaia De Angelis, Natascha Ilena Gray

Micrometer sized capsules are often used as single entities for the encapsulation and release of active ingredients, for example in food, cosmetics, and drug delivery. Important parameters that determine the stability of capsules and the release of reagent ...

WILEY2023

Repurposed drug combination via high-throughput screening and dual drug delivery system development for the treatment of retinoblastoma

Po-Jen Tseng

The goal of retinoblastoma (RB) treatment is to save the child's life, eyes and functional vision, with that order of priority. The management of RB is complex and involves strategically chosen methods of surgical enucleation, external beam radiotherapy, i ...

EPFL2022

Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes

Sandrine Gerber, Qixing Zhang, Yi Wang, Léo Bühler

Islet transplantation is a promising approach for the treatment of type 1 diabetes (T1D). Currently, clinical islet transplantation is limited by allo - and autoimmunity that may cause partial or complete loss of islet function within a short period of tim ...

2022

Advanced characterization of regioselectively substituted methylcellulose model compounds by DNP enhanced solid-state NMR spectroscopy

David Lyndon Emsley, Pierrick Berruyer, Pinelopi Moutzouri, Michel Bardet

Dynamic Nuclear Polarization MAS NMR is introduced to characterize model methylcellulose ether compounds at natural isotopic abundance. In particular an approach is provided to determine the position of the methyl ether group within the repeating unit. Spe ...

2021

Bioinspired Viscoelastic Capsules: Delivery Vehicles and Beyond

Esther Amstad, Gianluca Nicolas Etienne, Irvine Lian Hao Ong

Microcapsules are often used as individually dispersed carriers of active ingredients to prolong their shelf life or to protect premature reactions with substances contained in the surrounding. This study goes beyond this application and employs microcapsu ...

Wiley2019

Mechano-responsive microcapsules with uniform thin shells

Esther Amstad, Antoine Claude Jean Vian

Capsules often prolong the shelf-life of active ingredients, such as many types of drugs, food additives, or cosmetic substances, because they delay oxidation of these substances or prevent their reactions with molecules contained in the surrounding. If ca ...

2019

Capsules with submicron shells: production, stability, and leakage behavior

Antoine Claude Jean Vian

Capsules are often employed to prolong the shelf-life of active ingredients such as many drugs, food additives, or cosmetic substances because they delay their oxidation or prevent interactions with molecules contained in the surrounding. If designed prope ...

EPFL2018

In vitro Controlled Release from Solid Pharmaceutical Formulations of two new Adamantane Aminoethers with Antitubercular Activity (I)

Stewart Cole, Anthony Vocat

The aim of the present investigation was to develop matrix tablet formulations for the in vitro controlled release of 2 new tuberculocidal adamantane aminoethers (compounds I and II), congeneric to the adamantane derivative SQ109 , which is in final clinic ...

Georg Thieme Verlag Kg2017

Microfluidics: A Tool to Control the Size and Composition of Particles

Esther Amstad

Particles and capsules are used as containers for active ingredients to delay their degradation and control the location and kinetics of their release. Key to a successful application of these containers is a good control over their size, composition, and ...

Swiss Chemical Soc2017

Therapeutic Proteins Engineered for Super-Affinity to the Extracellular Matrix in Regenerative Medicine

Priscilla Suhasna Maithili Briquez

Regenerative medicine aims to repair body tissues when natural mechanisms fail. Growth factors (GFs) are essential proteins that promote tissue regeneration upon injury, and as such, are very promising therapeutic drugs in regenerative medicine. Due to the ...

EPFL2016