Publications associées à Parkine

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

Abstract The Wnt/β-catenin signalling and autophagy pathways each play important roles during development, adult tissue homeostasis and tumorigenesis. Here we identify the Wnt/β-catenin signalling pathway as a negative regulator of both basal and stress-in ...

Nature Publishing Group2013

LRRK2 secretion in exosomes is regulated by 14-3-3

Elpida Tsika, Darren Moore

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset Parkinson's disease (PD). Emerging evidence suggests a role for LRRK2 in the endocytic pathway. Here, we show that LRRK2 is released in extracellular microvesicles (i.e. exosomes) ...

Oxford University Press2013

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

Hilal Lashuel, Patrick Aebischer, Bernard Schneider, Abid Oueslati

An increase in α-synuclein levels due to gene duplications/triplications or impaired degradation is sufficient to trigger its aggregation and cause familial Parkinson disease (PD). Therefore, lowering α-synuclein levels represents a viable therapeutic stra ...

National Academy of Sciences2013

Neurodegenerative phenotypes in an A53T-synuclein transgenic mouse model are independent of LRRK2

Darren Moore, Alessandra Musso

Mutations in the genes encoding LRRK2 and -synuclein cause autosomal dominant forms of familial Parkinsons disease (PD). Fibrillar forms of -synuclein are a major component of Lewy bodies, the intracytoplasmic proteinaceous inclusions that are a pathologic ...

Oxford University Press2012

Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction

Hilal Lashuel

α-Synuclein can be degraded by both the ubiquitin-proteasomal system and the chaperone-lysosomal system. However, the switching mechanism between the two pathways is not clearly understood. In our study, we investigated the mutual association between the b ...

Academic Press Inc Elsevier Science2012

The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation

Hilal Lashuel, Mirva Hejjaoui, Mahmood Haj Yahya

A polyubiquitin chain anchored to the substrate has been the hallmark of proteasomal recognition. However, the degradation signal appears to be more complex and to contain also a substrate's unstructured region. Recent reports have shown that the proteasom ...

Cell Press2012

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

Liliane Glauser, Darren Moore, Sarah Catherine Sonnay, Klodjan Stafa

Mutations in the parkin gene cause early-onset, autosomal recessive Parkinson's disease. Parkin functions as an E3 ubiquitin ligase to mediate the covalent attachment of ubiquitin monomers or linked chains to protein substrates. Substrate ubiquitination ca ...

2011

Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36

Darren Moore

Parkinson disease (PD) is a relatively common neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. About 5%-10% of PD cases are inherited. Mutations in the Parkin gene, which encodes a pr ...

American Society for Clinical Investigation2011

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

Michaël Unser, Patrick Aebischer, Bernard Schneider, Daniel Sage, Samareh Azeredo da Silveira Lajaunias

Phosphorylation is involved in numerous neurodegenerative diseases. In particular, alpha-synuclein is extensively phosphorylated in aggregates in patients suffering from synucleinopathies. However, the share of this modification in the events that lead to ...

Oxford University Press2009

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Parkine

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

Overexpression of parkin in the rat nigrostriatal dopamine system protects against methamphetamine neurotoxicity

LRRK2 secretion in exosomes is regulated by 14-3-3

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

Neurodegenerative phenotypes in an A53T-synuclein transgenic mouse model are independent of LRRK2

Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction

The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

Graph Chatbot

Chattez avec Graph Search

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

Overexpression of parkin in the rat nigrostriatal dopamine system protects against methamphetamine neurotoxicity

Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

LRRK2 secretion in exosomes is regulated by 14-3-3

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

Neurodegenerative phenotypes in an A53T-synuclein transgenic mouse model are independent of LRRK2

Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction

The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1