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Ex vivo gene therapy is an interesting alternative to orthotopic liver transplantation (OLT) for treating metabolic liver diseases. In this study, we investigated its efficacy and biosafety in nonhuman primates. Hepatocytes isolated from liver lobectomy we ...
Providing accurate image-guidance for soft-tissue interventions remains a complex task. Most of the time, preoperative models and planning data are no more valid during the surgical process due to motions and deformations of the organ of interest. In this ...
Correct registration between pre-operative high-resolution images and intra-operative data of lower detail is a fundamental requirement in image-guided liver surgery. We propose a multi modality liver model for measuring the accuracy of such registration m ...
TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- a ...
Efficient computer assisted surgery dealing with soft tissues remains a complex task. In most cases, the preoperative information such as 3D organ reconstructions and the planning built upon are no longer valid during the surgical process itself due to the ...
More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in li ...
The purpose of this study was to prospectively compare the performance of magnetic resonance (MR) elastography using echo-planar and spin-echo imaging for staging of hepatic fibrosis. Twenty-four patients who had liver biopsy for suspicion of chronic liver ...
Efficient computer assisted surgery dealing with soft tissues remains a complex task. In most cases, the preoperative information such as 3D organ reconstructions and the planning built upon are no longer valid during the surgical process itself due to the ...
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The purpose of our study was to prospectively compare the success rate and diagnostic accuracy of magnetic resonance elastography, ultrasound elastography, and aspartate aminotransferase to platelets ratio index (APRI) measurements for the noninvasive stag ...
In the adult liver, 1,4-bis[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP), an agonist of the constitutive androstane receptor (CAR, NR1I3), produces rapid hepatomegaly in the absence of injury. In this study, we identify c-Myc as a gene induced by CAR and ...
