Concept

Hypothalamic–pituitary–thyroid axis

Publications associées (33)

Personality traits in rats predict vulnerability and resilience to developing stress-induced depression-like behaviors, HPA axis hyper-reactivity and brain changes in pERK1/2 activity

Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Cristina Marquez Vega, Jorge Eduardo Castro Cifuentes, Shanaz Diessler

Emerging evidence indicates that certain behavioral traits, such as anxiety, are associated with the development of depression-like behaviors after exposure to chronic stress. However, single traits do not explain the wide variability in vulnerability to s ...

Elsevier2012

Approximate Feedback Capacity of the Gaussian Multicast Channel

Michael Christoph Gastpar, Naveen Goela

We characterize the capacity region to within log {2(M − 1)} bits/s/Hz for the M -transmitter K -receiver Gaus- sian multicast channel with feedback where each receiver wishes to decode every message from the M transmitters. Extending Cover-Leung’s achieva ...

2012

Neurochemical profile of the mouse hypothalamus using in vivo1H MRS at 14.1T

Rolf Gruetter, Hongxia Lei, Carole Poitry-Yamate

The hypothalamus plays an essential role in the central nervous system of mammals by among others regulating glucose homeostasis, food intake, temperature, and to some extent blood pressure. Assessments of hypothalamic metabolism using, e.g. 1H MRS in mous ...

Wiley-Blackwell2010

Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism

Johan Auwerx

The multifactorial mechanisms promoting weight loss and improved metabolism following Roux-en-Y gastric bypass (GB) surgery remain incompletely understood. Recent rodent studies suggest that bile acids can mediate energy homeostasis by activating the G-pro ...

2009

The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice

Johan Auwerx, Kristina Schoonjans

The small heterodimer partner (SHP) is an atypical nuclear receptor known mainly for its role in bile acid homeostasis in the enterohepatic tract. We explore here the role of SHP in the testis. SHP is expressed in the interstitial compartment of the adult ...

2007

Identification of a novel modulator of thyroid hormone receptor-mediated action

Jordi Duran

Diabetes is characterized by reduced thyroid function and altered myogenesis after muscle injury. Here we identify a novel component of thyroid hormone action that is repressed in diabetic rat muscle. ...

Public Library of Science2007

Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects

Johan Auwerx

CONTEXT: The type 2 iodothyronine deiodinase (D2) catalyzes the conversion of T(4) to the active form of thyroid hormone, which is a critical regulator of thermogenesis and glucose metabolism. A Thr92Ala polymorphism in the gene encoding D2 (DIO2) has been ...

2006

Exposure to retrieval cues improves retention performance and induces changes in ACTH and corticosterone release

Maria del Carmen Sandi Perez

Memory retrieval can be facilitated by pretest exposure to cues associated with the original training. The present series of experiments was aimed at investigating whether the effectiveness of the retrieval cues might be due to their emotional value and th ...

2004

Glucocorticoids induce the expression of the leptin gene through a non-classical mechanism of transcriptional activation

Johan Auwerx

Leptin is a hormone which is produced in adipose tissue and which plays a role in the regulation of energy homeostasis. The expression of the ob gene, encoding leptin, is under multi-hormonal control. We have shown previously that high doses of glucocortic ...

1998

Hormonal regulation of the genes involved in lipoprotein metabolism in the rat [Contrôle hormonal des gènes impliqués dans le métabolisme lipoprotéique chez le rat]

Johan Auwerx

Despite the complex regulation of the expression of these genes, some general conclusions seem to be warranted. First, nearly all the studied genes are regulated in a tissue-specific fashion. Moreover hepatic expression seems to be more tightly controlled ...

1995

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