Publications associées à Optic tract

Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (μCAPs)

Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton, Farnaz Delavari, Nada Kojovic

The temporal variability of the thalamus in functional networks may provide valuable insights into the pathophysiology of schizophrenia. To address the complexity of the role of the thalamic nuclei in psychosis, we introduced micro-co-activation patterns ( ...

Wiley2024

Structure-function coupling increases during interictal spikes in temporal lobe epilepsy: A graph signal processing study

Dimitri Nestor Alice Van De Ville, Maria Giulia Preti, Patric Hagmann

Objective: Structure-function coupling remains largely unknown in brain disorders. We studied this coupling during interictal epileptic discharges (IEDs), using graph signal processing in temporal lobe epilepsy (TLE). ...

ELSEVIER IRELAND LTD2023

Three-dimensional multilayer concentric bipolar electrodes restrict spatial activation in optic nerve stimulation

Diego Ghezzi, Eleonora Borda, Marta Jole Ildelfonsa Airaghi Leccardi, Vivien Gaillet, Elodie Geneviève Zollinger, Ricardo Camilo Moreira

Objective. Intraneural nerve interfaces often operate in a monopolar configuration with a common and distant ground electrode. This configuration leads to a wide spreading of the electric field. Therefore, this approach is suboptimal for intraneural nerve ...

IOP Publishing Ltd2022

Fabrication and validation of an intraneural interface tailored for optic nerve stimulation

Eleonora Borda

Technological progress in materials science and microengineering along with new discoveries in neuroscience have contributed to restore lost or impaired sensory functions by closely interfacing with the nervous system. Electronic devices have begun to be i ...

EPFL2022

Homogeneous light stimulation of melanopsin and cones with a Maxwellian view device for the human eye

Gilles Evéquoz, Patrick Robert Flückiger

We designed and tested a device to stimulate specifically one photoreceptor type, or a combination of some of them, of the human eye by using up to six primaries. The device produces a homogeneous light field over 40 degrees which is projected onto the ret ...

IEEE2021

Organic semiconductors for light-mediated neuromodulation

Diego Ghezzi, Danashi Imani Medagoda

There is growing interest in organic semiconductor devices for light-mediated neuromodulation, such as for retinal stimulation. Here, the key working principles of these devices are discussed, as well as promising applications and outstanding challenges fo ...

SPRINGERNATURE2021

Investigation of electrical stimulation of the optic nerve for artificial vision

Vivien Gaillet

Thanks to recent technological advances in microelectronics and bioengineering, it is now possible to restore lost or impaired sensory modalities by interfering the nervous system with elec-tronic devices and artificially reproducing the electrical encodin ...

EPFL2021

Ophthalmic system and method for clinical device using transcleral illumination with multiple points source

Christophe Moser, Timothé Laforest, Mathieu Künzi

An ophthalmic illumination and imaging system with transscleral / transpalpebral illumination of the eye fundus comprises a light-delivering device with a plurality of emitting areas; each of the emitting areas being configured to be independently controll ...

2020

Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve

Silvestro Micera, Diego Ghezzi, Paola Vagni, Vivien Gaillet, Fiorenzo Artoni, Ariastity Mega Pratiwi, Dario Lipucci Di Paola

Retinal prostheses can restore a functional form of vision in patients affected by dystrophies of the outer retinal layer. Beyond clinical utility, prostheses for the stimulation of the optic nerve, the visual thalamus or the visual cortex could also serve ...

2020

A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology

Sameer Mohammad Khaleel Nazeeruddin

Tauopathies are neurodegenerative diseases whose common pathological feature is the intraneuronal accumulation of tau aggregates. Tau protein has various roles in the neuron, among which stabilization of microtubules (MT), regulation of synaptic activity o ...

EPFL2019